DARE2APPROACH
Financiado
Dare to Approach A Neurocognitive Approach to Alleviating Persistent Avoidance...
Dare to Approach A Neurocognitive Approach to Alleviating Persistent Avoidance in Anxiety Disorders
How did three soldiers override their initial freezing response to overpower an armed terrorist in the Thalys-train to Paris in 2015? This question is relevant for anyone aiming to optimize approach-avoidance (AA) decisions during...
How did three soldiers override their initial freezing response to overpower an armed terrorist in the Thalys-train to Paris in 2015? This question is relevant for anyone aiming to optimize approach-avoidance (AA) decisions during threat. It is particularly relevant for patients with anxiety disorders whose persistent avoidance is key to the maintenance of their anxiety.
Computational psychiatry has made great progress in formalizing how we make (mal)adaptive decisions. Current models, however, largely ignore the transient psychophysiological state of the decision maker. Parasympathetic state and flexibility in switching between para- and sympathetic states are directly related to freezing, and are known to bias AA-decisions toward avoidance. The central aim of this research program is to forge a mechanistic understanding of how we compute AA-decisions on the basis of those psychophysiological states, and to identify alterations in anxiety patients in order to guide new personalized neurocognitive interventions into their persistent avoidance.
I will develop a neurocomputational model of AA-decisions that accounts for transient psychophysiological states, in order to define which decision parameters are altered in active and passive avoidance in anxiety. I will test causal premises of the model using state-of-the-art techniques, including pharmacological and electrophysiological interventions. Based on these insights I will for the first time apply personalized brain stimulation to anxiety patients.
Clinically, this project should open the way to effective intervention with fearful avoidance in anxiety disorders that rank among the most common, costly and persistent mental disorders. Theoretically, conceptualizing transient psychophysiological states as causal factor in AA-decision models is essential to understanding passive and active avoidance. Optimizing AA-decisions also holds broad societal relevance given currently increased fearful avoidance of outgroups.
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Duración del proyecto: 78 meses
Fecha Inicio: 2018-05-03
Fecha Fin: 2024-11-30
Fecha Fin: 2024-11-30
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2018-05-03
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2017-COG:
ERC Consolidator Grant
Cerrada
hace 7 años
Presupuesto
El presupuesto total del proyecto asciende a
2M€
Líder del proyecto
STICHTING RADBOUD UNIVERSITEIT
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
821.52K€ |
Participante