FeSYM
Financiado
Cytosolic Iron Delivery for Symbiotic Nitrogen Fixation
Symbiotic nitrogen fixation (SNF) carried out by legume nodules is one of the most efficient ways of introducing nitrogen in natural ecosystems and in sustainable agriculture. It relies on the transfer of a relatively large amount...
Symbiotic nitrogen fixation (SNF) carried out by legume nodules is one of the most efficient ways of introducing nitrogen in natural ecosystems and in sustainable agriculture. It relies on the transfer of a relatively large amount of iron from the host plant to the endosymbiotic bacteria colonizing nodule cells, where it will be used as cofactor of many of the enzymes participating in SNF. However, the required steady iron supply for SNF is challenged by its low bioavailability in soil, prevalent in many of the main agricultural areas of the world. This is worsened by the hundreds of ferro-enzymes that compete for iron cofactors within a cell. Due to the relevance of SNF for a more sustainable agriculture, and the importance of ensuring iron supply to achieve this, a substantial effort has been done in understanding how legumes incorporate iron and deliver it to the nodules, and how it is used to synthesize nitrogenase cofactors. However, no information is available on how iron is specifically allocated to the nitrogen-fixing compartments. In this proposal we intend to study the mechanisms enabling targeted iron delivery to nitrogen fixation, particularly those events occurring at the cytosol and at the interface between the two symbionts. To do this, we will identify and characterize the proteins interacting the known symbiosome iron transporters. As a result, we will characterize the iron-interactome of these elements. These findings should not only increase our understanding of iron homeostasis in SNF and, more broadly, in plants, but also lead to dedicated iron delivery pathways for iron-biofortification or to engineer iron-proteins in plants.
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Duración del proyecto: 32 meses
Fecha Inicio: 2023-04-11
Fecha Fin: 2025-12-31
Fecha Fin: 2025-12-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-11
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
181K€
Líder del proyecto
UNIVERSIDAD POLITÉCNICA DE MADRID
No se ha especificado una descripción o un objeto social para esta compañía.
Total investigadores
3941
Total investigadores
3941