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GROWTHPATTERN

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Coordination Of Patterning And Growth In The Spinal Cord

Individuals of the same species vary widely in size, but their organs have reproducible proportions and patterns of cell types. How cell fate specification and tissue growth are coordinated during embryonic development to achieve... ver más

30/06/2021

IST AUSTRIA

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-06-30

ERC-StG-2015: ERC Starting Grant

I+D

Cerrada hace 10 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

IST AUSTRIA

1.50M€ | Lider

GRUPO TAVEX

420.24K€ | Participante

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Duración del proyecto: 65 meses Fecha Inicio: 2016-01-21
Fecha Fin: 2021-06-30

Líder del proyecto

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Individuals of the same species vary widely in size, but their organs have reproducible proportions and patterns of cell types. How cell fate specification and tissue growth are coordinated during embryonic development to achieve this reproducibility is a fundamental question in biology. Yet, surprisingly little is known about the underlying mechanisms. A major challenge has been to obtain the quantitative data required to assess the dynamics and variability in growth, pattern and signalling by morphogens – molecules that regulate both cell fate specification and tissue growth. I recently established experimental and theoretical approaches that allowed me to reconstruct with unprecedented resolution the three-dimensional growth and pattern of mouse and chick spinal cord. My data revealed a previously unanticipated role of tissue growth dynamics in controlling pattern reproducibility. This quantitative framework provides an exciting opportunity to elucidate the biophysical and molecular mechanisms of growth and pattern coordination. I will use this unique position to understand: 1) how signalling by multiple morphogens is integrated to control pattern, 2) how morphogens control cell cycle kinetics, 3) how morphogen source and target tissue are coupled to achieve pattern reproducibility. To address these issues, I will build on my experience with quantitative analyses to design novel assays where signalling, cell cycle dynamics and transcriptomes can be precisely measured and manipulated with single cell resolution. I will exploit state-of-the-art genome editing techniques to uncouple the critical feedback links and gain a novel perspective on pattern reproducibility and morphogen function. The project will advance our fundamental understanding of tissue morphogenesis and provide novel insights relevant to understanding information processing by signal transduction cascades, morphogen gradient activity, tissue engineering, and cancer biology.

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