Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MechaPattern

Financiado

Cerrado

Coordination between cell identity tissue mechanics and proportionate patternin...

Coordination between cell identity tissue mechanics and proportionate patterning during vertebrate eye formation The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently.... ver más

25/08/2021

CSIC

161K€

Presupuesto del proyecto: 161K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-25

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

160.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2011-24701 BASES CELULARES Y MOLECULARES DE LA MORFOGENESIS DEL OJO DE... 128K€ Cerrado

PID2020-113647GA-I00 COORDINACION ENTRE LA IDENTIDAD CELULAR Y LA MECANICA DE LOS... 103K€ Cerrado

BFU2014-55918-P MECANISMOS MOLECULARES IMPLICADOS EN LA MORFOGENESIS DEL OJO... 133K€ Cerrado

EYEDEVELOPMENT Molecular genetic regulation of eye field development 100K€ Cerrado

RYC-2010-05656 Coordination of cell movement during eye morphogenesis in de... 192K€ Cerrado

ZEYMORPH Celluar and Molecular Bases of Vertebrate Eye Morphogenesis 100K€ Cerrado

Duración del proyecto: 28 meses Fecha Inicio: 2019-03-29
Fecha Fin: 2021-08-25

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 161K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The development of an organ requires the precise coordination between pattern formation, morphogenetic movements and the final size of the system. Significant progress has been made in understanding these processes independently. The aim of this proposal is to integrate this information by analyzing coordination hubs, such as the crosstalk between YAP/TAZ and Wntβ-catenin pathways during the specification of the identity and the mechanical properties of the cell. I will use the development of the vertebrate eye as a defined paradigm. To identify intrinsic and relevant properties of this system, the two most powerful and amenable models of eye morphogenesis will be analyzed: the self-generation of 3D optic cups from mouse Embryonic Stem Cells and the in vivo development of the teleost eye. The plan is to generate a spatiotemporal activation map of the main determinants of eye identity and use them to link morphogen signaling with key morphogenetic processes in specific cells. This will be the groundwork to identify the role of retinal pigmented epithelial (RPE) cells during optic cup folding, the context that I will use to understand both the coordination between morphogen patterning (Wnt) and mechanical properties (Yap) of the retinal precursors, and between proportionated patterning and eye size (scale-invariant mechanisms). This proposal relies on the collaboration of multiple experts from the host institute and on the use of already developed bona fide protocols, reporter lines and signaling perturbations experiments, but revisited with cutting-edge technologies, such as light sheet microscopy and computational modeling. Thus, it is an extremely innovative but feasible project to understand deep-root questions of organ formation. Moreover, this interdisciplinary project will open unprecedented opportunities in the field of organ regeneration from a comprehensive morphogenetic perspective, which will be the foundation of my future independent research.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores