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NR-NET

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Cerrado

Control of metabolic and inflammatory pathways by nuclear receptors

NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to ch... ver más

31/12/2017

BIOMEDICALSCIENCES...

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 10 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-12-31 No tenemos la información de la convocatoria

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

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10 Participantes

BIOMEDICALSCIENCES RESEARCH...

0.00€ | Lider

UNIBA

N.D. | Participante

UDG

N.D. | Participante

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Líder del proyecto

EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alterations, we propose that they could be considered as important endogenous modulators of metaflammatory pathways further expanding the repertoire of diseases that can be intervened by NR-modulating drugs. NR-NET is expected to deliver important new knowledge on the basic biological processes involved in the mechanism of epigenetic control of gene expression by nuclear receptors, on structural and functional aspects of nuclear receptor action with an ultimate goal of better understanding the pathogenesis of metabolic disorders and inflammation. The composition of the network was designed to contain a balanced mix of labs with experience and skills in academic and industry based research, so that it can provide young researchers the opportunity to acquire skills and expertise in: a. Structural and functional aspects of NR-regulated gene expression b. Genomics and proteomics approaches to analyze complex regulatory networks c. Systems biology approaches and bioinformatics tools to define composite regulatory modules d. Studying metabolic and inflammatory pathways in model organisms The research will be conducted under the framework of a structured training program, which includes a myriad of Individual and Network-wide training activities. Apart from training in academic and industry-based research projects, specific emphasis will be given to training in transferable skills and the stimulation of creativity and entrepreneurial mindset of researchers.

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