COSY-BIO
Financiado
Control Engineering of Biological Systems for Reliable Synthetic Biology Applica...
Synthetic Biology aims at rational engineering of living organisms to improve human well-being and environmental sustainability, thus promising a paradigm shift in human technology. Its full potential has not been achieved yet bec...
Synthetic Biology aims at rational engineering of living organisms to improve human well-being and environmental sustainability, thus promising a paradigm shift in human technology. Its full potential has not been achieved yet because of the complexity of engineering biological systems where basic biological parts are intrinsically noisy and not modular. The overarching goal of COSY-BIO is to develop a theoretical framework and innovative technological tools to engineer reliable biological systems that are robust despite their individual components being not by translating principles of control engineering to molecular and cell biology. Automatic control is a well-established engineering discipline to build controllers to steer the dynamic behaviour of a physical system in a desired fashion. By building upon control engineering for physical systems and by exploiting the unique features of living organisms, this project will identify generally applicable approaches to design closed-loop feedback controllers for biological systems. To handle biological complexity, the project will explore three strategies of increasing difficulty external controllers, embedded controllers and multi-cellular controllers. External controllers will be implemented in a computer acting on cells using small molecules via microfluidics devices. Embedded controllers will be made from biological parts and integrated within individual cells to steer their behaviour. Multicellular controllers envisage two cell populations, one made up of cells with embedded controllers (controller cells) and the other will be the controlled population (target cells). In addition, a rapid prototyping platform will enable to speed up the design-build-test cycles by means of optimal experimental design, microfluidics and cell-free systems. Proof-of-principles demonstrations in bacteria and yeast with relevance to biotechnology will be tackled to prove the usefulness of this revolutionary technology.
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Duración del proyecto: 43 meses
Fecha Inicio: 2017-08-24
Fecha Fin: 2021-03-31
Fecha Fin: 2021-03-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2021-03-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
FETOPEN-01-2016-2017:
FET-Open research and innovation actions
Cerrada
hace 8 años
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
FONDAZIONE TELETHON ETS
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
222.26K€ |
Participante
72.32K€ |
Participante
398.53K€ |
Participante