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CONstrainCONverge

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Constrained convergence: does pleiotropy constrain convergent alpine adaptation?

Is evolution predictable? In CONstrainCONverge, I aim to understand evolutionary mechanisms governing predictability in adaptive evolution, by asking why some genes are more likely reused by adaptation than others. Despite a rich... ver más

31/08/2025

310K€

Presupuesto del proyecto: 310K€

Líder del proyecto

UNIVERZITA KARLOVA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-06-08

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

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2 Participantes

309.77K€ | Lider

UNIVERSITAET BERN

N.D. | Participante

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Duración del proyecto: 38 meses Fecha Inicio: 2022-06-08
Fecha Fin: 2025-08-31

Líder del proyecto

UNIVERZITA KARLOVA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 310K€

Descripción del proyecto Is evolution predictable? In CONstrainCONverge, I aim to understand evolutionary mechanisms governing predictability in adaptive evolution, by asking why some genes are more likely reused by adaptation than others. Despite a rich theoretical background, systematic analysis of the mechanisms underlying convergence is lacking in complex multicellular organisms. That limits application of convergent evolutionary concepts in repeated evolution of socio-economically relevant traits such as resistance to pathogens, pesticides or pollution. To fill in this gap, I will study genetic constraints of convergent adaptation towards stressful alpine environments in plant model genus Arabidopsis. Eight independently evolved populations of alpine Arabidopsis provide a unique model of environmental adaptation, allowing to leverage an unprecedented range of genetic and experimental resources to address fundamental evolutionary questions. During my PhD I characterized this system from a population genomic point of view, preparing a ground for experimental genetic validations. In the outgoing phase, I will bring this experience to the host lab of Prof. Peichel at the University of Bern (UBERN), an expert in the evolutionary genetics of convergence in fishes. Systematic training in the host lab and three international research visits will broaden my bioinformatics and experimental skills. I will learn new multidisciplinary approaches bridging the fields of evolutionary genomics and molecular genetics through the combination of transcriptomics, statistical genomics, and functional experiments. I will return to Charles University (CU) to share the newly gained skills with local researchers and gain further training in functional genetics and transferable skills under the supervision of Prof. Lafon Placette, aiming to improve my teaching and leadership skills and establish my own research group in evolutionary genetics, a virtually non-existent field in Czech research environment.

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