Innovating Works

COMP-O-CELL

Financiado
Computational Microscopy of Cells
As an integral part of cell architecture, cell membranes are central to cell functioning. Comprising a heterogeneous mixture of proteins and lipids, cell membranes are constantly adapting their structural organization to regulate... As an integral part of cell architecture, cell membranes are central to cell functioning. Comprising a heterogeneous mixture of proteins and lipids, cell membranes are constantly adapting their structural organization to regulate cellular processes. Malfunction at the level of lipid-protein interaction is implicated in numerous diseases , and hence, understanding cell membrane organization at the molecular level is of critical importance. Unfortunately, our current understanding is limited, which is due to the lack of methods for studying these fluctuating nanoscale assemblies in vivo at the required spatiotemporal resolution. An important tool for studying cellular processes is through molecular simulation, denoted computational microscopy. Computational microscopy has been used to study small membrane patches in isolation, but until now, cell membranes have not been simulated in their ‘natural’ context. I intend to apply computational microscopy at the whole-cell level, to study complex membrane structures and their function within the cellular environment. This requires challenging methodological innovations at the crossroads of biology, life sciences, physics, and chemistry. In this project, I will use advanced computational microscopy to study the interplay of membranes with their surroundings in a realistic cellular environment. The main goal is to establish a framework for the simulation, at molecular resolution, of entire cells and cell organelles. ver más
31/08/2027
2M€
Duración del proyecto: 63 meses Fecha Inicio: 2022-05-25
Fecha Fin: 2027-08-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-05-25
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2021-ADG: ERC ADVANCED GRANTS
Cerrada hace 3 años
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
RIJKSUNIVERSITEIT GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5