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COMENZE

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Computational and Experimental Enzyme Engineering for New Polymers

Polymeric materials are ubiquitous in our daily lives but they have a predominantly fossil origin, with low degradability at their end-of-life. Transitioning to a circular polymer economy requires a rethinking of the entire value... ver más

28/02/2029

UNL

Presupuesto desconocido

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UNIVERSIDADE NOVA DE LISBOA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto

HORIZON-MSCA-2023-DN-01-01: MSCA Doctoral Networks 2023 Expected Outcome:Project results are expected to contribute to the following outcomes:

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Duración del proyecto: 47 meses Fecha Inicio: 2025-03-01
Fecha Fin: 2029-02-28

Líder del proyecto

UNIVERSIDADE NOVA DE LISBOA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Polymeric materials are ubiquitous in our daily lives but they have a predominantly fossil origin, with low degradability at their end-of-life. Transitioning to a circular polymer economy requires a rethinking of the entire value chain, from the raw materials, tools, and processes used to polymer design degradation and recycling. Enzymes are eco-friendly and sustainable tools that tackle many industrial applications. However, biocatalysis in the polymer field remains mostly unexplored due to i) enzymes’ high cost and low stability under reaction conditions, ii) enzymes’ inefficiency in converting bio-based monomers into cost-effective building blocks, and iii) lack of knowledge in key enzyme-polymer interactions that can control the final polymer performance and degradability features. Computational tools have shown immense power to revolutionize the field of enzyme engineering in a time and cost effective way. However, there is currently a clear lack of researchers combining computational and experimental skills, capable of determining future directions for the optimization of biocatalytic processes for the sustainable molecular design of polymers. To foster the transition to a bio-based polymer industry, COMENZE aims to develop enzymatic strategies for improving the eco-design and development of future sustainable polymers. This will be achieved by combining cutting-edge computational and experimental approaches for enzyme discovery and engineering through in-silico modeling, simulation, and translation of results into wet labs to validate enzymatic reactions. COMENZE will train the next generation of researchers by equipping 10 DCs with the skills to revolutionize the polymer circularity by delivering new optimized enzymes and bioprocesses, newly identified bio-based building blocks, and functionalized polymers with innovative bio-upcycling and biodegradation end-of-life options.

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