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Combination of Shear Stress and Molecular Imaging of Inflammation to Predict Hig...

Combination of Shear Stress and Molecular Imaging of Inflammation to Predict High Risk Atherosclerotic Plaque Although the detailed pathophysiologic triggers responsible for the individual natural history trajectory of each atherosclerotic plaque are unknown, the local, dynamic interplay between low endothelial shear stress (ESS) and vasc... ver más

11/04/2014

ARISTOTLE UNIVERSI...

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

ARISTOTELIO PANEPISTIMIO THESSALONIKIS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-04-11 No tenemos la información de la convocatoria

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

ARISTOTLE UNIVERSITY OF THES...

0.00€ | Lider

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Líder del proyecto

ARISTOTELIO PANEPISTIMIO THESSALONIKIS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Although the detailed pathophysiologic triggers responsible for the individual natural history trajectory of each atherosclerotic plaque are unknown, the local, dynamic interplay between low endothelial shear stress (ESS) and vascular inflammation is likely to be critical. The purpose of the proposed project is to combine ESS with inflammation in a plaque risk classification scheme aiming to predict high-risk plaque at early stages of its development before its rupture. Enhancing our understanding of the magnitude of local hemodynamic stimulus with respect to inflammation (i.e. ESS), as well as the extent of local inflammation would allow us to detect early, minimally stenotic, atherosclerotic lesions and stratify the risk of them evolving into high-risk plaques. The latter classification is of utmost clinical importance as it can provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary patients, as well as the prevention of acute coronary syndrome. Identification of a high-risk plaque at its early stages of development would potentially justify highly selective, prophylactic local interventions, such as implantation of stents or targeted nanoparticle-based delivery of anti-inflammatory drugs, supplemented by an intensive systemic pharmacologic approach to limit the severity of inflammation, stabilize the plaque, and thereby avert a future acute coronary event. The clinical and economic implications of identifying and treating high-risk individual coronary lesions before an adverse cardiac event can occur are anticipated to be enormous.

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