Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HELP

Financiado

Cerrado

Collaboration for innovation Establishment of a pan nematode drug development p...

Collaboration for innovation Establishment of a pan nematode drug development platform To target helminth elimination, a drug research and development (R&D) pipeline is needed to provide new chemotherapeutics that effectively eliminate or sterilize adult worms, thus bringing about the paradigm shift necessary to rea... ver más

28/02/2026

SWISS TPH SWISS TR...

9M€

Presupuesto del proyecto: 9M€

Líder del proyecto

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INST... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 10 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-04-30

SC1-BHC-15-2018: New anti-infective agents for preve...

I+D

Cerrada hace 7 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

10 Participantes

SWISS TPH SWISS TROPICAL AND...

3.29M€ | Lider

THE REGISTERED TRUSTEES OF T...

Pasan SA

N.D. | Participante

Bayer Animal GmbH, an Elanco...

N.D. | Participante

Proyectos interesantes

STOP2030

Medical Technol...

Public Health

4M€ Cerrado

SAF2015-66690-R

Medical Technol...

Pharmaceutical...

145K€ Cerrado

RTI2018-093940-B-I00

Medical Technol...

Pharmaceutical...

194K€ Cerrado

PID2021-127471OB-I00

Medical Technol...

Pharmaceutical...

158K€ Cerrado

STTDAA

Medical Technol...

Chemical Engine...

174K€ Cerrado

PID2020-119035RB-I00

Medical Technol...

Data Science

212K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 81 meses Fecha Inicio: 2019-04-30
Fecha Fin: 2026-02-28

Líder del proyecto

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INST... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 9M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto To target helminth elimination, a drug research and development (R&D) pipeline is needed to provide new chemotherapeutics that effectively eliminate or sterilize adult worms, thus bringing about the paradigm shift necessary to reach the 2030 SDG goals on health. Our consortium proposes to establish a R&D pipeline for anthelminthics targeting nematodes. The focus will be on soil-transmitted helminthiasis and onchocerciasis, since these infections are among the leading neglected tropical diseases. Ground breaking characteristics of the drugs developed within our project are that they will have a unique mechanism of action that, at best, will target multiple nematodes (pan-nematode) with an excellent safety profile, including no efficacy against non-targeted co-endemic species. We will benefit from collaborations with our industrial partners Bayer and Celgene providing preselected compounds to populate the early preclinical stages of the R&D pipeline. Compounds with the best profile will be progressed through preclinical studies. Corallopyronin A, a compound with proven efficacy against essential Wolbachia endosymbionts in filariae that has superiority to the gold standard doxycycline, excellent bioavailability and promising exploratory safety data will undergo state-of-the-art toxicity profiling to advance towards phase 1 trials. We will also evaluate oxfendazol and oxantel pamoate in clinical trials. They have already proven efficacious in animals or humans and will only require clinical trials according to current regulatory guidelines to be implemented. With this strategy, the consortium will ensure that a pipeline of drug candidates is available for treating onchocerciasis, especially should current candidates fail in upcoming clinical trials. Moreover, we will establish a much-needed drug R&D pipeline to treat soil-transmitted helminth infections for which there is currently neither a drug with good efficacy against all species nor any prospects on the horizon.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores