Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ChromoSilence

Financiado

Cerrado

Chromosome based mechanisms of transcriptional inactivation during mitosis

Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival. It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activit... ver más

30/09/2026

FUNDACAO CALOUSTE...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FUNDACAO CALOUSTE GULBENKIAN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-05

ERC-2020-COG: ERC CONSOLIDATOR GRANTS

I+D

Cerrada hace 5 años

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

FUNDACAO CALOUSTE GULBENKIAN

2.00M€ | Lider

CEPSA QUÍMICA,

785.45K€ | Participante

Proyectos interesantes

CHROMDECON

Medical Technol...

Applied Physics

1M€ Cerrado

MitErrA

Medical Technol...

Applied Physics

1M€ Cerrado

BFU2009-08213

Medical Technol...

Applied Physics

219K€ Cerrado

CHROMSTAB

Medical Technol...

Applied Physics

100K€ Cerrado

BFU2011-27568

Medical Technol...

Applied Physics

99K€ Cerrado

BFU2013-43718-P

Medical Technol...

Applied Physics

230K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 66 meses Fecha Inicio: 2021-03-05
Fecha Fin: 2026-09-30

Líder del proyecto

FUNDACAO CALOUSTE GULBENKIAN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival. It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activity. While Mitotic Transcriptional Inactivation (MTI) is entrenched as a dogma in cell biology, its functional consequences have been difficult to pin down, as manipulating MTI in the context of a developing organism has been difficult until now. My lab has pioneered the use of acute perturbation approaches to dissect cellular process with unprecedented temporal resolution, which hold the prospect of surpassing current limitations on the identification and manipulation of multiple MTI layers. Using these novel approaches, ChromoSilence aims to test the hypothesis that MTI is a vital process for proper genome partitioning and transcriptional control. We will focus our analysis on chromosome-based events, that we propose as key contributors for MTI regulation, and test how classic chromosome assembly factors impact on mitotic transcriptional shutdown. In parallel, and supported by strong preliminary observations for a putative candidate, we will identify and reveal the function of novel players involved in chromosome-based mechanisms to drive MTI. New knowledge on the MTI mechanisms will be used to develop tools to uncover the role of this transcriptional shutdown in the fidelity of nuclear division and thereby identify novel routes to maintenance of genome stability. We will additionally uncover how the transcriptional silencing during mitosis may impact on maintenance of transcriptional programs in various developmental contexts. Collectively, ChromoSilence will reveal that MTI is not a by-product of passage through mitosis but instead an essential process for accurate chromosome segregation, maintenance of cell identity and organism development.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores