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INVERT2ADAPT

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Chromosomal inversions in Atlantic herring and adaptation to changing sea water...

Chromosomal inversions in Atlantic herring and adaptation to changing sea water temperature Large chromosomal inversions have been increasingly linked to local adaptation in natural populations. Despite their importance, there is current debate about what evolutionary forces maintain inversion polymorphisms in natural po... ver más

30/06/2024

207K€

Presupuesto del proyecto: 207K€

Líder del proyecto

UPPSALA UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-06-30

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

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Cerrada hace 3 años

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1 Participantes

206.89K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2022-06-10
Fecha Fin: 2024-06-30

Líder del proyecto

UPPSALA UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 207K€

Descripción del proyecto Large chromosomal inversions have been increasingly linked to local adaptation in natural populations. Despite their importance, there is current debate about what evolutionary forces maintain inversion polymorphisms in natural populations, particularly regarding the interplay between balancing and divergent selection. Furthermore, limitations of sequencing technologies often result in poor characterization of inversion breakpoints obscuring our understanding of their functional impact. INVERT2ADAPT will focus on Atlantic herring (Clupea harengus) as a model system to study the contribution of chromosomal inversions to local adaptation using multiple genomics tools. First, I will characterize the chromosomal inversions and date their origin relatively to the evolutionary history of Atlantic herring using comparative genomics and phylogenomics. Second, I will study the selection regimes that maintain the inversions across a gradient of sea water temperate using population genomics. Lastly, I will pinpoint the genes and regulatory elements within the inversions that are involved in adaptation to sea water temperature using gene expression and functional genomics. The project will allow to better understand how Atlantic herring is able to survive across a wide range of sea water temperature in the Atlantic Ocean. A clear establishment of the link between linking genotype, phenotype and environment is important to understand how Atlantic herring might adapt to changes in sea water temperature induced by global warming. INVERT2ADAPT will also contribute to a better understanding of how structural variation, including large chromosomal inversions, contribute to adaptation in natural populations. The project will be implemented in Uppsala University under the supervision of Professor Leif Andersson.

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