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CHLOE-PET

Financiado

CHerenkov Light mOdulE for time-of-flight Positron Emission Tomography

Time-of-flight positron emission tomography (TOF-PET) is the standard-of-care in cancer detection. TOF-PET scanners’ performance is dependent on the radiation detectors they use. Improving time and spatial detection features in su... ver más

31/08/2027

INSTITUT DE FÍSICA...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT DE FÍSICA D`ALTRES ENERGIES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 4M€

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-09-29

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

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1 Participantes

INSTITUT DE FÍSICA D`ALTRES...

1.38M€ | Lider

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Duración del proyecto: 59 meses Fecha Inicio: 2022-09-29
Fecha Fin: 2027-08-31

Líder del proyecto

INSTITUT DE FÍSICA D`ALTRES ENERGIES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 4M€

Presupuesto del proyecto 1M€

Descripción del proyecto Time-of-flight positron emission tomography (TOF-PET) is the standard-of-care in cancer detection. TOF-PET scanners’ performance is dependent on the radiation detectors they use. Improving time and spatial detection features in such detectors will dramatically impact the diagnostic capacity of TOF-PET systems. The goal of this project is to build a gamma detector concept for TOF-PET able to improve the time resolution and spatial segmentation of state-of-the-art detectors by a factor of up to 7 and 10, respectively, without additional production costs. CHLOE-PET is a forward-looking gamma detector design for TOF-PET able to exploit the new photodetector technologies that are currently under development and will become available within the next 5-to-10 years. The novelty of the proposed design lies in using Cherenkov light as a prompt time source, using an innovative geometry optimized to maximize light collection, and employing photodetectors with small pixel pitch. This project is the first attempt to build a detector module scalable to a full-size system that can be used in a hospital setting. The CHLOE-PET detector will consist of bismuth germanate (BGO) crystals with 12 mm thickness and will combine the readout of scintillation and Cherenkov light. CHLOE-PET will provide an effective 3D segmentation of 2x2x2 mm3, an intrinsic photon time spread of 20 ps, and no intrinsic radiation background (unlike state-of-the-art TOF-PET detectors). Such improvements will allow increasing the signal-to-noise ratio of images by >2-fold, to be able to detect lesions of 2 mm size (>3 times the current performance), to build portable high-performance organ-dedicated TOF-PET systems, and to universalize the use of dynamic TOF-PET studies. The combination of these outcomes will provide significantly better diagnostic capabilities in a range of fields such as oncology, neurology, or cardiology, among others, and ultimately boost treatment efficacy and patient comfort.

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