Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MERCURY

Financiado

Cerrado

Chemical compounds targeting MERCs identification of their partners in physiolo...

Chemical compounds targeting MERCs identification of their partners in physiological and pathological conditions Mitochondria and Endoplasmic Reticulum (ER) Contact sites (MERCs) are points in which the surfaces of the two organelles run in parallel. MERCs gained attention recently due to their fundamental contribution to several cell proces... ver más

31/07/2023

UNIPD

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PADOVA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-07-31

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIPD

183.47K€ | Lider

Proyectos interesantes

OrgaNet

Medical Technol...

Applied Physics

1M€ Cerrado

ERMITO

Medical Technol...

Applied Physics

1M€ Cerrado

MITOCHONTACTS

Medical Technol...

Applied Physics

183K€ Cerrado

PalmERa

Medical Technol...

Applied Physics

2M€ Cerrado

PID2020-116086RB-I00

Medical Technol...

Applied Physics

303K€ Cerrado

ER ARCHITECTURE

Medical Technol...

Applied Physics

1M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 39 meses Fecha Inicio: 2020-04-01
Fecha Fin: 2023-07-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PADOVA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Mitochondria and Endoplasmic Reticulum (ER) Contact sites (MERCs) are points in which the surfaces of the two organelles run in parallel. MERCs gained attention recently due to their fundamental contribution to several cell processes, such as Ca2+ and lipid homeostasis, mitochondrial fission, and apoptosis. To execute and regulate these processes, MERCs must be dynamic and react to the needs and metabolic state of the cell. Interestingly, the organelles stay separated by a narrow cleft, usually 10-50 nm apart. The width of the MERCs gap and its size (i.e. area of a membrane involved in the contacts) are the critical parameters that determine their cellular functions. Despite the literature on MERCs has grown considerably, the precise molecular structure and role of MERCs are poorly defined. In the proposed project I will investigate the regulation of MERCs plasticity by small molecule compounds. Using a high-content phenotypic screening approach, based on a FRET mitochondria-ER proximity probe, I will identify the compounds affecting MERCs structure. These bioactive hits will be validated through biochemical, confocal and electron microscopy assays. Moreover, I will search for the protein target of the hit molecule using the methodology developed during my PhD. Finally, I will evaluate the capability of the identified hit molecules to act as therapeutic lead compounds for pathological conditions by testing the identified molecules on cells with defective MERCs. Therefore, this project will open new research paths related to both MERCs structure and function. I will obtain deep knowledge of mitochondrial biology and high content screening, which will complement my current expertise obtained during PhD. Besides, I will develop transferable skills needed to successfully accomplish the proposed project. The project also brings the benefits to the European Research Area, since it builds international collaboration and transfers knowledge between two research areas/teams.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores