Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CEREBRALfungi

Financiado

CharactERizing the neuronal Effects of BehavioRAL-modifying proteins from the zo...

CharactERizing the neuronal Effects of BehavioRAL-modifying proteins from the zombie FUNGI, Ophiocordyceps, using C. elegans Ophiocordyceps unilateralis is a species complex of entomopathogens known for their ability to manipulate the behavior of infected ants (zombie ants). While these behavioral effects are well described, the molecular basis for beha... ver más

31/07/2025

203K€

Presupuesto del proyecto: 203K€

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-20

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

203.46K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ZOMBIHAVIOUR Leveraging the zombie-making strategies of Ophiocordyceps fu... 2M€ Cerrado

NeuRemodelBehavior Sculpting circuits and behavior by developmental neuronal re... 3M€ Cerrado

PID2020-115088RB-I00 CLUSTERING AUTOMATICO DE COMPORTAMIENTOS DE INVERTEBRADOS EN... 150K€ Cerrado

BFU2011-24315 ESPECIFICACION DE DESTINOS NEURONALES EN EL DESARROLLO DEL S... 237K€ Cerrado

C.NAPSE TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDIN... 2M€ Cerrado

PID2019-110952GB-I00 HOUSE KEEPING GENES KEEPING EVERY NEURON DIFFERENT 109K€ Cerrado

Duración del proyecto: 28 meses Fecha Inicio: 2023-03-20
Fecha Fin: 2025-07-31

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 203K€

Descripción del proyecto Ophiocordyceps unilateralis is a species complex of entomopathogens known for their ability to manipulate the behavior of infected ants (zombie ants). While these behavioral effects are well described, the molecular basis for behavioral manipulation is still being explored. During my current postdoctoral fellowship with the National Science Foundation USA, I have identified a set of putative behavioral effectors and am currently utilizing the model organism yeast to express these biomolecules and test their behavioral effects in ants. This proposal will build on my previous work by utilizing another model organism, C. elegans, to analyze the transferability of these effectors to other animal models and to understand their effect on core neurological pathways. To accomplish this goal, I will collaborate with the Van den Heuvel lab at Utrecht University, a developmental biology team known for their excellence in the imaging of nematodes. Their access to a pre-established C. elegans Yeast-Two-Hybrid library and experience with the genetic modification of nematodes will be paramount in addressing three research objectives set for this project: identifying the biological targets of behavior-modifying effectors using Yeast-Two-Hybrid mating, analyzing the behavioral effects of these effectors via transgenic expression in C. elegans, and evaluating tissue-specific changes at the molecular level in C. elegans using mass spec. Such a project spans many biological subdisciplines, and thus, lends itself well to the international exchange of personnel, advanced training, and ideas, allowing me to make use of my experience with molecular cloning and acquire new skills handling and observing C. elegans. Furthermore, the study of Ophiocordyceps effectors present an innovative approach towards new drug discovery, particularly those with the potential to treat behavioral disorders as fungal secondary metabolites are often used for medications, impacting the public in a positive way.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores