Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

GUT IMMUNITY GRNS

Financiado

Cerrado

Characterizing the Gene Regulatory Networks Mediating Gut Immunocompetence in Dr...

Characterizing the Gene Regulatory Networks Mediating Gut Immunocompetence in Drosophila The emergence of a gastrointestinal tract within the body cavity is one of the major innovations in animal evolution allowing the transition from an intra- to an extracellular mode of digestion. With this emergence came the opport... ver más

31/08/2016

EPFL

269K€

Presupuesto del proyecto: 269K€

Líder del proyecto

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-08-31 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

EPFL

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CeleSte Commensal microbiota regulation of neuro immune networks 148K€ Cerrado

ILCSIGNALLING Deciphering cell cell and cell microbiome interactions of in... 171K€ Cerrado

Signalling-in-NODs Investigation of the role and mechanism of action of NOD2 me... 195K€ Cerrado

T Cell Feedback T cell regulation by fed state bacterial metabolites 1M€ Cerrado

GUTDROSO Gut immunity and homeostasis in Drosophila 1M€ Cerrado

IDENSTEM Identification and characterization of enteric nervous syste... 213K€ Cerrado

Líder del proyecto

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 269K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The emergence of a gastrointestinal tract within the body cavity is one of the major innovations in animal evolution allowing the transition from an intra- to an extracellular mode of digestion. With this emergence came the opportunity for infectious agents to exploit this intestinal ecosystem for their own transmission. Gut-bearing organisms therefore evolved complex mechanisms to defend themselves against these agents, making them gut immunocompetent. This involved a process of continuous adaptation and counter-adaptation in the two competing species, host and pathogen, rendering gut immunocompetence a complex trait with a large genetic component. Important progress has been made to elucidate the biological processes underlying gut immunocompetence, revealing an intricate interplay between immunological, stress, and neuronal signaling as well as gut regeneration and wound repair. However, how this multilayered regulatory network is encoded at the molecular level and how genetic variation of the host species contributes to this trait is still poorly understood. Here, we propose a global and interdisciplinary study, combining regulatory genomics and bioinformatics, to elucidate the genetic and molecular mechanisms underlying gut immunocompetence and its variation in Drosophila melanogaster. By determining the regulatory targets of transcription factors involved in the interplay between the immune response pathways, relating them to known physiological outputs, and computationally mining the genetic variants that may lie at the basis of the observed phenotypic variation, we expect to elucidate the regulatory networks mediating gut immunocompetence and how they are impacted by genomic variation. This would not only constitute a breakthrough in the field of innate immunity, but a sound foundation for understanding the molecular driving forces that impact genetic variation of a complex trait in general.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores