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HIV VCC Interference

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Characterisation of single molecule dynamics within HIV 1 reservoirs as a target...

Characterisation of single molecule dynamics within HIV 1 reservoirs as a target for interference with virus persistence and immune evasion Human Immunodeficiency Virus type 1 (HIV-1) remains a significant cause of comorbidity and mortality around the world. One of HIV-1 persistence and immune evasion mechanisms is the ability to create hidden virus reservoirs in cell... ver más

31/12/2020

FUNDACIO PRIVADA I...

158K€

Presupuesto del proyecto: 158K€

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FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SI... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 5M€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-12-31

MSCA-IF-2017: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

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1 Participantes

FUNDACIO PRIVADA INSTITUT DE...

158.12K€ | Lider

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Duración del proyecto: 33 meses Fecha Inicio: 2018-03-26
Fecha Fin: 2020-12-31

Líder del proyecto

FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SI... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 5M€

Presupuesto del proyecto 158K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Human Immunodeficiency Virus type 1 (HIV-1) remains a significant cause of comorbidity and mortality around the world. One of HIV-1 persistence and immune evasion mechanisms is the ability to create hidden virus reservoirs in cells. These virus reservoirs, termed Virus-Containing Compartments (VCCs) are inaccessible to the immune system and help to spread the infection to different parts of the body. VCCs are unaffected by current HIV-1 therapies, and thus remain a major obstacle in the development of successful HIV-1 cure strategies. This project will take a novel approach to the interference with this mechanism of HIV-1 persistence by characterising and exploiting unique molecular dynamics inside VCCs in dendritic cells. Cutting edge super-resolution microscopy techniques enable the study of single molecule behaviour and have already been employed to investigate the minute details of virus-cell interactions during HIV-1 assembly, entry and cell-to-cell spread. These interactions were shown to depend on a specific arrangement and mobility of virus and cell molecules suggesting that efficient virus sequestration and release from VCCs may also require a specific distribution and dynamics of interacting lipids and proteins. Specifically, the HIV VCC Interference project aims to: 1) characterise the distribution and dynamics of lipids and proteins in VCCs as a whole and at the sites of virus-cell interactions using super-resolution microscopy; 2) assess the unique characteristics of these sites as targets for interference with HIV-1 persistence and to explore the potential of these targets by testing drugs that perturb specific aspects of cell membranes. These studies, which are aligned with objectives of MSCA-IF, will lead to the description of novel single molecule details of VCC environments and the characterisation of a new type of HIV-1 therapy that targets virus persistence by interfering with unique membrane properties of virus reservoirs.

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