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DIAGORAS

Financiado

Cerrado

Chair bedside diagnosis of oral and respiratory tract infections and identifica...

Chair bedside diagnosis of oral and respiratory tract infections and identification of antibiotic resistances for personalised monitoring and treatment The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral disease... ver más

31/05/2019

HSG-IMIT

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

HAHNSCHICKARDGESELLSCHAFT FUR ANGEWANDTE FORS... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 12 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-05-31

PHC-10-2014: Development of new diagnostic tools... Scope:Specific challenge: The development of new diagnostics (more sensitive, robust and selective)...

I+D

Cerrada hace 11 años

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Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

12 Participantes

HSG-IMIT

985.38K€ | Lider

POSTRES LACTEOS ROMAR

298.76K€ | Participante

Askion GmbH

499.25K€ | Participante

MagnaMedics

398.32K€ | Participante

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Duración del proyecto: 50 meses Fecha Inicio: 2015-03-27
Fecha Fin: 2019-05-31

Líder del proyecto

HAHNSCHICKARDGESELLSCHAFT FUR ANGEWANDTE FORS... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The project aims at diagnosing oral and respiratory tract infections (RTIs) using a fully integrated, automated and user-friendly platform for physicians’ offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalized monitoring. RTIs (e.g., tonsillitis, pharyngitis, rhinitis, sinusitis) will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial vs viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. High impact is expected on socioeconomic level too, as the healthcare system is expected to benefit from: less crowded hospitals (patients find equally efficient chair-side diagnosis); less budget spent on excessive antibiotics and progressed-stage disease treatments; less insurance costs for oral diseases, which are largely age-related. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated reader) integrating all components and assays for a fully-automated analysis: interface of the collection tube with the disposable disc; on-disc sample preparation (nucleic acid extraction and purification with pre-stored buffers); amplification & detection (rapid PCR); protein isolation and detection (bead-based multiplexed immunoassays); microarray-based antibiotic screening. Low-cost disposable fabrication (microthermoforming of polymer foils) will render the platform batch-producible and affordable to end users. The entire setup will be validated at clinical settings and compared with gold standards (e.g., tissue extraction and culture methods). The modular nature of the platform, the non-invasive sampling, the rapid and multiplexed molecular-based detection, and the sample-to-answer analysis are DIAGORAS innovative features.

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