IP2adapt
Financiado
Cell-specific functional connectivity of cerebellar outputs for locomotor learni...
Everyday behaviours, like mastering dance moves or hiking through uneven terrains, require motor learning. Although essential, cellular and circuit mechanisms for this type of learning are poorly understood.
In the context of loc...
Everyday behaviours, like mastering dance moves or hiking through uneven terrains, require motor learning. Although essential, cellular and circuit mechanisms for this type of learning are poorly understood.
In the context of locomotion, learning can be induced on a split-belt treadmill, where each side of the body moves at different speeds; this is currently used as a rehabilitative therapy in patients presenting asymmetric gaits following brain damage. The receiving laboratory recently showed that mouse locomotor learning is remarkably similar to humans. Regaining gait symmetry is achieved through specific adjustments in interlimb coordination. Moreover, the laboratory demonstrated that this form of motor learning depends critically on intermediate cerebellum. Strikingly, spatial and temporal components of learning (i.e. where and when paws land) proceeded independently, suggesting that they might be dissociable at the neural circuit level. However, how cerebellar outputs act to calibrate spatiotemporal coordination between limbs is unknown.
IP2adapt aims to decipher the functional connectivity of cerebellar output circuits conveying corrective calibration signals to modify locomotor movements in space and time. Specifically, we will: 1) Use advanced viral tools to map output circuits downstream of the cerebellum and identify candidates for spatial and temporal calibration signals; 2) Use high-resolution quantitative behavioural analysis and cutting-edge circuit manipulation to test specific functional roles of projection-defined subsets of cerebellar outputs in locomotor learning; 3) Use state-of-the-art recordings of these functionally-defined neurons during learning to understand how the cerebellum transforms locomotor errors into spatial and temporal calibration of limb movement.
This work will reveal unprecedented insights into neural circuits that ensure the adaptability of motor commands, with direct relevance for rehabilitative therapy.
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Duración del proyecto: 37 meses
Fecha Inicio: 2022-07-26
Fecha Fin: 2025-08-31
Fecha Fin: 2025-08-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-07-26
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01:
MSCA Postdoctoral Fellowships 2021
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
157K€
Líder del proyecto
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR....
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Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5