Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

IP2adapt

Financiado

Cell-specific functional connectivity of cerebellar outputs for locomotor learni...

Everyday behaviours, like mastering dance moves or hiking through uneven terrains, require motor learning. Although essential, cellular and circuit mechanisms for this type of learning are poorly understood. In the context of loc... ver más

31/08/2025

FUNDACAO CHAMPALIM...

157K€

Presupuesto del proyecto: 157K€

Líder del proyecto

FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR.... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-07-26

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021

I+D

Cerrada hace 3 años

0% 100%

1 Participantes

FUNDACAO CHAMPALIMAUD

156.78K€ | Lider

Proyectos interesantes

MotMotLearn Motivating Motor Learning The Role of Reward Punishment an... 1M€ Cerrado

PSI2011-28388 ESTUDIO DE LOS MECANISMOS DE REORGANIZACION DE LA CONECTIVID... 91K€ Cerrado

simSpas Development of a simulation platform to study the role of jo... 192K€ Cerrado

PSI2015-71061-P TRANSFERENCIA INTERHEMISFERICA DEL APRENDIZAJE MOTOR A TRAVE... 52K€ Cerrado

EIN2019-103510 BIO-MARCADORES NEURO-MECANICOS DE ENFERMEDADES NEUROLOGICAS 10K€ Cerrado

RTC-2017-6298-7 Rehabilitación y Evaluación de la Asimetria de la Marcha y l... 197K€ Cerrado

Últimas noticias

27-11-2024: Videojuegos y creaci... Se abre la línea de ayuda pública: Ayudas para la promoción del sector del videojuego, del pódcast y otras formas de creación digital

27-11-2024: DGIPYME En las últimas 48 horas el Organismo DGIPYME ha otorgado 1 concesiones

27-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 2 concesiones

Duración del proyecto: 37 meses Fecha Inicio: 2022-07-26
Fecha Fin: 2025-08-31

Presupuesto del proyecto 157K€

Descripción del proyecto Everyday behaviours, like mastering dance moves or hiking through uneven terrains, require motor learning. Although essential, cellular and circuit mechanisms for this type of learning are poorly understood. In the context of locomotion, learning can be induced on a split-belt treadmill, where each side of the body moves at different speeds; this is currently used as a rehabilitative therapy in patients presenting asymmetric gaits following brain damage. The receiving laboratory recently showed that mouse locomotor learning is remarkably similar to humans. Regaining gait symmetry is achieved through specific adjustments in interlimb coordination. Moreover, the laboratory demonstrated that this form of motor learning depends critically on intermediate cerebellum. Strikingly, spatial and temporal components of learning (i.e. where and when paws land) proceeded independently, suggesting that they might be dissociable at the neural circuit level. However, how cerebellar outputs act to calibrate spatiotemporal coordination between limbs is unknown. IP2adapt aims to decipher the functional connectivity of cerebellar output circuits conveying corrective calibration signals to modify locomotor movements in space and time. Specifically, we will: 1) Use advanced viral tools to map output circuits downstream of the cerebellum and identify candidates for spatial and temporal calibration signals; 2) Use high-resolution quantitative behavioural analysis and cutting-edge circuit manipulation to test specific functional roles of projection-defined subsets of cerebellar outputs in locomotor learning; 3) Use state-of-the-art recordings of these functionally-defined neurons during learning to understand how the cerebellum transforms locomotor errors into spatial and temporal calibration of limb movement. This work will reveal unprecedented insights into neural circuits that ensure the adaptability of motor commands, with direct relevance for rehabilitative therapy.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores