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AmpliFISH

Financiado

Bright nanoparticle probes for amplified fluorescence in situ hybridization in c...

Bright nanoparticle probes for amplified fluorescence in situ hybridization in cancer diagnostics Rapidly expanding field of cancer diagnostics generates strong demand for new biosensing tools. In particular, it concerns probes for fluorescence in situ hybridization (FISH), that enables detection of DNA and RNA cancer biomarke... ver más

31/05/2022

UNISTRA

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

UNIVERSITE DE STRASBOURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-05-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2019-POC: ERC Proof of Concept Grant

I+D

Cerrada hace 5 años

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2 Participantes

UNISTRA

150.00K€ | Lider

PELETS COMBUSTIBLE DE LA MAN...

825.48K€ | Participante

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 26 meses Fecha Inicio: 2020-03-10
Fecha Fin: 2022-05-31

Líder del proyecto

UNIVERSITE DE STRASBOURG

TRL 4-5

Presupuesto del proyecto 150K€

Descripción del proyecto Rapidly expanding field of cancer diagnostics generates strong demand for new biosensing tools. In particular, it concerns probes for fluorescence in situ hybridization (FISH), that enables detection of DNA and RNA cancer biomarkers directly in diseased cells. Although FISH technique has already been accepted for cancer diagnostics in clinics, its applications are still limited because the method is slow, expensive and requires complicated amplification protocols to obtain sufficient fluorescence signal. Here, we propose a solution based on ultrabright DNA-functionalized dye-loaded fluorescent polymeric nanoparticles recently developed within the ERC grant BrightSens and protected by two patent applications. We aim to develop ultrabright FISH probes (nanoprobes) for cancer research and clinical diagnostics. These nanoprobes will feature single-molecule DNA/RNA sensitivity, low cost, fast and direct one step cell staining protocol, and compatibility with clinical samples and single-cell assays. The amplification of FISH performance will be ensured by our dye-loaded polymeric nanoparticles of 7-20 nm size that are ~1000 fold brighter than single organic dyes. The project is composed of five tasks: (1) Synthesis and optimization of FISH nanoprobes; (2) validation of FISH nanoprobes in cancer cell lines; (3) development of multiplexing assays for detection at least 9 biomarkers; (4) their validation in clinically relevant samples; and, finally, (5) commercialization of FISH nanoprobes. The developed probes will constitute highly competitive products that can greatly improve performance of FISH assays in clinics and research laboratories and thus impact human health. Therefore, they will be directly proposed for commercialization by licensing to existing companies and/or through creation of a startup.

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