Innovating Works

LaserBlood

Financiado
Biophotonic Nanoparticle-enabled Laser Blood Test for Early Detection of Pancrea...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of cancer that is on the rise due to various factors, including an aging population and unhealthy lifestyles. Regrettably, PDAC is among the top cancer killers, with a dism... Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of cancer that is on the rise due to various factors, including an aging population and unhealthy lifestyles. Regrettably, PDAC is among the top cancer killers, with a dismal five-year survival rate of less than 10%. The lack of adequate screening programs is a significant factor contributing to this dire statistic. However, the identification of PDAC in its early stages could help reduce the mortality rate by as much as 80%. The project LASERBLOOD (Biophotonic Nanoparticle-enabled Laser Blood Test for Early Detection of Pancreatic Cancer) aims to develop an in vitro diagnostic test based on the fluorescence lifetime fingerprint of the personalized protein corona, offering critical information at every stage of PDAC progression. The protein corona (PC) is a coating of bio-molecular substances surrounding nanoparticles when exposed to biofluids. It is both personalized and disease-specific, making it an ideal marker to monitor the variation of nanoparticle PC and correlate it to the development of PDAC. The analysis will use fluorescence lifetime (FL) analysis, a non-invasive, reactant-free, and real-time technique. In the initial phase, the consortium will utilize a mouse model (MKC) to identify the FL fingerprint of protein corona at each stage of PDAC development. The MKC mouse model is genetically engineered to be bioluminescent and develop PDAC in a controlled manner. By linking the development of PDAC observed through bioluminescent imaging to the FL response of PC in blood samples, the consortium will provide an unprecedented fingerprint of the disease's progression from its first occurrence. At a second stage, the project will validate on humans the use of the FL fingerprint of protein corona as a tool for the early diagnosis of PDAC. The findings will provide the scientific and technological foundation for the development of an in vitro PDAC test for large scale screening of the population. ver más
31/12/2027
FLIM LABS
3M€
Duración del proyecto: 50 meses Fecha Inicio: 2023-10-27
Fecha Fin: 2027-12-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-27
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2023-PATHFINDEROPEN-01-01: EIC Pathfinder Open
Cerrada hace 1 año
Presupuesto El presupuesto total del proyecto asciende a 3M€
Líder del proyecto
FLIM LABS SRL No se ha especificado una descripción o un objeto social para esta compañía.