Time2SWITCH
Financiado
Bioorthogonal Iontronic Chemistry: Spatiotemporal Drug Release with Electronic P...
I envision a new drug delivery system capable spatiotemporal release with electronic precision.This technology is based on; Biontronic Chemistry (BC) which combines Bioorthogonal Release (BR) and Iontronic transport to overcome th...
I envision a new drug delivery system capable spatiotemporal release with electronic precision.This technology is based on; Biontronic Chemistry (BC) which combines Bioorthogonal Release (BR) and Iontronic transport to overcome the drawbacks of each individual technology and combine their unique advantages. An electronic ion pump (IP) will enable programable electrophoretic transport of chemical triggers without liquid flow or moving mechanical parts to initiate the ultrafast & selective bioorthogonal release (BR) of drugs at the target site to generate previously unobtainable dynamic concentration-time profiles. Hence, BC translates electrical stimuli, of arbitrary frequencies and amplitudes, into tailor-made bio-chemical concentration/time profiles. By incorporating surface release functionalities and orthogonal bioorthogonal chemistries I will further expand the concept and demonstrate choreographed cascade releases to afford individually programmable release of multiple compounds with distinct concentration/time profiles. We will map out this large parameter space using a combination of rational chemical design, computationally aided device physics and engineering, fluorescent model systems and finally evaluation in cell models. T2S will lay the foundation for new directions in science and offer unprecedented opportunities for various therapies wherein choreographed, spatiotemporal control of multiple drug release is key (e.g. cancer; nerve regeneration and aging). My hypothesis is that if we combine local drug delivery and chronotherapy, we can dramatically increase treatment efficacy and reduce (if not completely) eliminate side effects. My overarching goal is to create a Switch that elevates medicine to the 5th dimension (5D) thus paving the way towards a paradigm shift in drug delivery and our understanding/ability to manipulate biological-spacetime by delivering the right dose (1D) at the right place (3D) at the right time (1D).
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Duración del proyecto: 59 meses
Fecha Inicio: 2024-09-01
Fecha Fin: 2029-08-31
Fecha Fin: 2029-08-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-09-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2023-STG:
ERC STARTING GRANTS
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
1M€
Líder del proyecto
TECHNISCHE UNIVERSITAET WIEN
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5