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PancmiR

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Biomimetic collagen-based scaffolds for the study of pancreatic cancer and deliv...

Biomimetic collagen-based scaffolds for the study of pancreatic cancer and delivery anti-tumoural miRNA for enhanced cancer therapy. Pancreatic tumours are among the most aggressive, and are associated with the lowest survival rates. The main reason of this is their characteristic dense fibrotic stroma, which creates a perfect environment to promote cancer prog... ver más

31/07/2026

ROYAL COLLEGE OF S...

200K€

Presupuesto del proyecto: 200K€

Líder del proyecto

ROYAL COLLEGE OF SURGEONS IN IRELAND No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 1 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-12

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

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ROYAL COLLEGE OF SURGEONS IN...

199.69K€ | Lider

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Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 27 meses Fecha Inicio: 2024-04-12
Fecha Fin: 2026-07-31

Líder del proyecto

ROYAL COLLEGE OF SURGEONS IN IRELAND

TRL 4-5

Presupuesto del proyecto 200K€

Descripción del proyecto Pancreatic tumours are among the most aggressive, and are associated with the lowest survival rates. The main reason of this is their characteristic dense fibrotic stroma, which creates a perfect environment to promote cancer progression. To accurately mimic the Extracellular Matrix (ECM) is challenging, but is essential to understanding the interaction that occurs during malignant transformation. KRAS mutation is the most frequent alteration in pancreatic cancer. Micro(mi)RNA-143-3p and miRNA-216b have been shown to decrease KRAS gene expression and suppress tumour cell growth. My overarching Aim is to generate a 3D model of pancreatic cancer in which I can test the ability of a miRNA-activated scaffold to suppress tumour growth and facilitate local delivery of miRNA (miRNA-143-3p and miRNA-216b) that downregulate KRAS expression. Prof. Fergal O’Brien’s group in Royal College of Surgeon in Ireland has an extensive experience with development of biomimetic scaffolds to recreate the tumoural ECM and activating scaffolds to release therapeutic molecules (e.g., miRNAs). Using techniques established in his group, I will develop a 3D collagen-based scaffold that recreates the structure of pancreatic tumour ECM and then utilise this form as miRNA-activated scaffolds that will be used as local delivery systems in a radical new treatment for this disease. I will be supervised by Prof. O’Brien, and he will guide my Career Development Plan. I will develop complementary skills in project management, leadership, entrepreneurship, commercialisation, dissemination, and profile enhancement. Acquiring advanced research competences and complementary skills, I will maturate as an independent scientist, enhancing my professional visibility, capacity, and competitiveness in the field of biomaterials. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own biomaterials research group.

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