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4D-BIOMAP

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Biomechanical Stimulation based on 4D Printed Magneto Active Polymers

MAPs are polymer-based composites that respond to magnetic fields with large deformation or tuneable mechanical properties. I aim to apply heterogeneous 3D printed MAPs as modifiable substrates to support biological structures whi... see more

31/12/2025

UC3M

1M€

Project Budget: 1M€

Project leader

UNIVERSIDAD CARLOS III DE MADRID No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 1341

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-10-27

ERC-2020-STG: ERC STARTING GRANTS Scope:Objectives

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Cerrada does 5 years

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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2 Participantes

UC3M

1.50M€ | Leader

OASA TRANSFORMADORES XXI, S....

1.18M€ | participant

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Project duration: 62 months Date Start: 2020-10-27
End date: 2025-12-31

Project leader

UNIVERSIDAD CARLOS III DE MADRID No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 1341

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description MAPs are polymer-based composites that respond to magnetic fields with large deformation or tuneable mechanical properties. I aim to apply heterogeneous 3D printed MAPs as modifiable substrates to support biological structures which can have their deformation state and stiffness controlled by the external application of magnetic stimuli. Such mechanical stimulation has an important role on biological structures leading to alterations in functional responses, morphological changes and activation of growth or healing processes. Current bottlenecks preventing progress in this field are a lack of: a) appropriate experimental methodologies to enable characterisation of the behaviour of these materials; b) fundamental theoretical underpinnings to support the design and application of these new materials. The first step is to undertake in depth characterisation and assessment of 4D printed MAPs to create a detailed understanding of the underlying physics controlling the interactions between the polymeric matrices and embedded magnetic particles during application of mechanical and/or magnetic loadings. I will then culture biological structures on the novel 4D printed MAPs to create a ‘designed’ biostructure with specified and controllable responses to a given magnetic stimulus. These novel biostructures will be assessed using three applications: a) astrocyte cellular networks, b) neuronal circuits and c) astrocyte-neuronal networks. The evaluation of cellular damage, morphological and physiological alterations will validate the performance of the new biostructures and also contribute new understanding to the effects of deformation and stiffness gradients during glial scarring on physiological functions of central nervous system cells. The resulting deep understanding of magneto-mechanics of MAPs and their further development for controllable stimulation devices, will enable the international consolidation of my research group within the mechanics and bioengineering fields.

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