Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

BIO2008-05284-C02-02

Financiado

BIOLOGIA MOLECULAR DE ISLAS DE PATOGENICIDAD DE STAPHYLOCOCCUS AUREUS

STAPHYLOCOCCUS AUREUS IS A HAZARDOUS PATHOGEN BOTH FOR HUMANS AND ANIMALS DUE TO THE ENORMOUS VARIETY OF INFECTIONS IT PRODUCES AND THE EMERGENCE OF MULTIDRUG-RESISTANT STRAINS, S, AUREUS IS THE MOST COMMON CAUSE OF SKIN INFECTION... ver más

01/01/2008

IVIA

276K€

Presupuesto del proyecto: 276K€

Líder del proyecto

IVIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 3M€

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2008-01-01

0% 100%

Participantes

IVIA

Lider

Proyectos interesantes

BIO2008-05284-C02-01 CARACTERIZACION MOLECULAR DE LA FUNCION DEL SISTEMA SENSORIA... 269K€ Cerrado

BIO2017-83035-R CARACTERIZACION FUNCIONAL DE LOS DETERMINANTES MOLECULARES P... 267K€ Cerrado

SAF2014-56986-R TRANSFERENCIA HORIZONTAL DE FACTORES DE VIRULENCIA CONTENIDO... 145K€ Cerrado

BES-2009-024827 BIOLOGIA MOLECULAR DE ISLAS DE PATOGENICIDAD DE STAPHYLOCOCC... 43K€ Cerrado

PCIN-2015-151 STAPHYLOCOCCUS AUREUS INTRACELULAR: DESCIFRANDO LOS FACTORES... 142K€ Cerrado

EEBB-I-12-03946 CARACTERIZACION MOLECULAR DE LA FUNCION DEL SISTEMA SENSORIA... 7K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Líder del proyecto

IVIA

TRL 4-5 | 3M€

Presupuesto del proyecto 276K€

Descripción del proyecto STAPHYLOCOCCUS AUREUS IS A HAZARDOUS PATHOGEN BOTH FOR HUMANS AND ANIMALS DUE TO THE ENORMOUS VARIETY OF INFECTIONS IT PRODUCES AND THE EMERGENCE OF MULTIDRUG-RESISTANT STRAINS, S, AUREUS IS THE MOST COMMON CAUSE OF SKIN INFECTIONS AND ONCE IT PENETRATES THE SUBCUTANEOUS TISSUES AND REACHES THE BLOOD IT CAN INFECT ALMOST ANY ORGAN, THE ENORMOUS PATHOGENIC EFFICIENCY OF S, AUREUS RELIES ON ITS CAPACITY TO PERSIST AND MULTIPLY IN DIFFERENT ENVIRONMENTS AS WELL AS ON ITS CAPACITY TO PRODUCE A LARGE VARIETY OF TOXINS, MOST OF WHICH ARE ENCODED IN MOBILE PATHOGENICITY ISLANDS, WE HYPOTHESIZE THAT BOTH ADAPTATION TO DIFFERENT ENVIRONMENTS AND MOBILITY-DISSEMINATION OF PATHOGENICITY ISLANDS HARBOURING TOXIN GENES ARE REGULATED BY THE BACTERIAL SENSORIAL SYSTEM, S, AUREUS AND BACTERIA IN GENERAL HAVE DEVELOPED SIGNAL TRANSDUCTION SYSTEMS TO TRANSMIT THE STIMULI TO THE CELLULAR MACHINERY, A KEY ELEMENT OF THE BACTERIAL SENSORIAL SYSTEMS IS THE TWO-COMPONENT PHOSPHORELAY SYSTEM (TCS) THAT CONSISTS OF A MEMBRANE BOUND SENSOR, WHICH RESPONDS TO AN EXTRACELLULAR SIGNAL BY PHOSPHORYLATING A CYTOSOLIC RESPONSE REGULATOR, ALTHOUGH MANY BACTERIA CONTAIN VARIOUS DOZENS OF TCS, CLASSICAL GENETIC STRATEGIES HAVE INFERRED THE FUNCTION OF TCS FROM THE PHENOTYPES DISPLAYED BY MUTANTS IN SINGLE TCS, WITHOUT CONSIDERING THAT THE REMANT MEMBERS OF THE FAMILY MIGHT EXERT COMPENSATORY OR INTERFERING EFFECTS, THUS, IN THIS COORDINATED PROJECT, SUBPROJECT 1 PROPOSES A GLOBAL STRATEGY TO ANALYZE THE TCS SENSORIAL SYSTEM BASED ON THE ANALYSIS OF A RECOMBINANT STRAIN IN WHICH ALL THE NON-ESSENTIAL TCS (FIFTEEN) PRESENT IN THE GENOME OF S, AUREUS WILL BE DELETED, THEN, USING THE REVERSE PROCESS, A COLLECTION OF DERIVATIVES OF THE MUTANT STRAIN CONTAINING A CHROMOSOMAL COPY OF EACH TCS WILL BE GENERATED, THE ANALYSIS OF THIS COLLECTION OF STRAINS WILL ALLOW US TO DETERMINE THE EXTENT OF BIOLOGICAL PROCESS AFFECTED BY TCS SENSORIAL SYSTEM, PAYING SPECIAL ATTENTION TO BIOFILM FORMATION, INTERACTION WITH HOST CELLS AND VIRULENCE,SUBPROJECT 2 IS DEVOTED TO THE MOLECULAR CHARACTERIZATION OF THE MOBILITY-DISSEMINATION CYCLE OF PATHOGENICITY ISLANDS OF S, AUREUS, PATHOGENICITY ISLANDS ARE LARGELY RESPONSIBLE FOR THE WIDE VARIETY OF ADAPTATIONS TO LIFE IN DIFFERENT ENVIRONMENTS, HOST TISSUES AND ANTIBIOTIC RESISTANCE, ITS MOBILITY IS A HIGHLY REGULATED PROCESS THAT DEPENDS ON PARTICULAR ENVIRONMENTAL CONDITIONS, INITIALLY, SUBPROJECT 2 WILL ANALYZE THE ELEMENTS INVOLVED IN THE EXCISION-REPLICATION-PACKAGING OF S, AUREUS PATHOGENICITY ISLANDS AND AFTERWARDS THIS SUBPROJECT WILL EXPLOIT THE COLLECTION OF MUTANT STRAINS CONTAINING SINGLE TCS OR DEFICIENT IN TCS TO EVALUATE THE ROLE OF TCS IN THE REGULATION OF THE MOBILITY OF PATHOGENICITY ISLANDS AND THE PRODUCTION OF TOXINS ENCODED BY THEM IN RESPONSE TO ENVIRONMENTAL SIGNALS,KEEPING IN MIND THAT TCS DO NOT EXIST IN HUMANS, THE RESULTS OF THIS PROJECT MIGHT BE USEFUL TO EVALUATE THE POTENTIAL OF TCS AS NEW TARGETS FOR DEVELOPING OF ANTIMICROBIALS AND/OR INHIBITORS THAT PREVENTED DISSEMINATION OF VIRULENCE FACTORS ENCODED IN MOBILE ELEMENTS, Staphylococcus aureus\sistemas sensoriales\sistemas de dos-componentes\islas de patogenicidad\fagos\biofilm\virulencia\transferencia horizontal de genes

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores