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ConfiMet

Financiado

Bioinspired Oxidation of Hydrocarbons in Confined Spaces

Selective functionalization of C-H bonds in hydrocarbons is a grand challenge that chemists have tried to address for decades drawing inspiration from enzymatic oxidation reactions, with limited success. The mimicry of metalloenzy... ver más

31/12/2024

UDG

181K€

Presupuesto del proyecto: 181K€

Líder del proyecto

UNIVERSITAT DE GIRONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 226

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-29

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021

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Cerrada hace 3 años

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2 Participantes

UDG

181.15K€ | Lider

FUNDACIO INSTITUT CATALA D'I...

N.D. | Participante

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 28 meses Fecha Inicio: 2022-08-29
Fecha Fin: 2024-12-31

Líder del proyecto

UNIVERSITAT DE GIRONA

Total investigadores 226

Presupuesto del proyecto 181K€

Descripción del proyecto Selective functionalization of C-H bonds in hydrocarbons is a grand challenge that chemists have tried to address for decades drawing inspiration from enzymatic oxidation reactions, with limited success. The mimicry of metalloenzymes has typically focused on the metal center, overlooking crucial aspects of the enzymatic machinery: secondary coordination effects, molecular recognition, and confinement within the isolated active site of the protein. Herein, well-established coordination manifolds for Fe- and Mn-based oxidation of C-H bonds will be melded to a synthetic molecular receptor. The novelty of the resulting metallo-cavitand receptors lies in the positioning of the reactive metal center in close proximity to a binding pocket with robust molecular recognition features. The proposed reactions will exploit a structured microenvironment based on carefully designed non-covalent interactions. The designed hosts will bind hydrocarbons and related substrates in a confined space in close proximity to a reactive metal species, promoting site-selective oxidation dictated by the orientation of the substrate within the receptor rather than by the innate reactivity of the different C-H bonds in the structure. ConfiMet will deliver unprecedented site-selective functionalization reactions in molecules with multiple chemically equivalent C-H bonds, of important impact in the development of sustainable production methods for drugs and other chemical specialties. This project is a unique opportunity for the researcher to combine existing skills in coordination chemistry and transition metal catalysis with supramolecular chemistry concepts. The stimulating environment provided by the Institute of Computational and Catalysis, a research unit of excellence at Universitat de Girona (Spain), will allow the candidate to develop leadership, communication, and independent thinking skills, enhancing her career prospects in the transition to an independent academic position.

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