BOW
Financiado
Biogenic Organotropic Wetsuits
Extracellular vesicle (EVs) nanoparticles are the universal agents of intercellular and inter-organismal communication made by cells for cells to shuttle lipids, proteins and nucleic acids, EVs mediate physiological processes and...
Extracellular vesicle (EVs) nanoparticles are the universal agents of intercellular and inter-organismal communication made by cells for cells to shuttle lipids, proteins and nucleic acids, EVs mediate physiological processes and help to spread various diseases, including cancer and infections. Their innate navigation performances take origin in the unique structure and composition of their membrane (which is to date inaccessible to synthetic mimics). The main goal of the BOW project is to explore and consolidate the technology able to impart biological surface precision, circulation and targeting abilities of EVs to superparamagnetic nanodevices (Magnetic Bead Devices, MBDs) by dressing them with a single- or multi-layer wetsuit of EV membrane fabric. This will proof and set a general, viable paradigm to recapitulate key biomimetic functions – including camouflage to the immune system and organ site/tumor targeting – to any synthetic nanodevice, while being disruptive as a first example of biogenic nanotechnology. If successful, such a non-incremental technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and clinical translation, contributing to strengthen and keep in the lead position European biotechnology and impacting life quality for people. Major objectives include: (i) production high-grade EVs with biomimetic and organotropic functions, (ii) synthesis and functionalization of MBDs, (iii) engineering a microfluidic device for streamlined fabrication of EV membrane coated MBDs (evMBDs) (iv) evaluation of evMBD biological performances and nanotoxiciy in-vitro, ex-vivo and in-vivo. BOW will be made possible thanks to a balanced ecology-biology-biophysics-chemistry-engineering matrix, of well-established and internationally recognized academics (7), high biotech SMEs (3), plus 1 innovation consulting, contributing to strengthen European pool of expertise and biotechnology innovation eco-system.
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Duración del proyecto: 53 meses
Fecha Inicio: 2020-05-28
Fecha Fin: 2024-10-31
Fecha Fin: 2024-10-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2024-10-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
FETPROACT-EIC-05-2019:
FET Proactive: emerging paradigms and communities
Cerrada
hace 5 años
Presupuesto
El presupuesto total del proyecto asciende a
4M€
Líder del proyecto
CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO D...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
312.18K€ |
Participante