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Neurofibres

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Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord...

Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation... ver más

30/06/2021

SERVICIO DE SALUD...

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

SERVICIO DE SALUD DE CASTILLA LA MANCHA Actividades hospitalarias organismos publicos

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-06-30

FETPROACT-01-2016: FET Proactive: emerging themes and...

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8 Participantes

SERVICIO DE SALUD DE CASTILL...

951.84K€ | Lider

CITRICOS DE MURCIA

331.99K€ | Participante

USAAR

680.00K€ | Participante

THE CHANCELLOR MASTERS AND S...

708.09K€ | Participante

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Duración del proyecto: 56 meses Fecha Inicio: 2016-10-27
Fecha Fin: 2021-06-30

Líder del proyecto

SERVICIO DE SALUD DE CASTILLA LA MANCHA Actividades hospitalarias organismos publicos

TRL 4-5 | 50K€

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation and fibrosis compromise device functionality. In Neurofibres we want to achieve a breakthrough in Neuroregenerative Bio-electronics, developing dual-function devices that will serve as electroactive scaffolds for CNS regeneration and neural circuit activation. We engineered electroconducting microfibres (MFs) that add negligible tissue insult while promoting guided cell migration and axonal regeneration in rodents with spinal cord injury (SCI). The MFs also meet the challenge of probe miniaturisation and biofunctionalisation for ultrasensitive recording and stimulation of neural activity. An interdisciplinary consortium composed of neuroscientists, medical specialists, researchers in biomaterials, protein engineering, physics, and electrical and mechanical engineering, together with a company specialised in fabrication of microcables and microconnectors, will join efforts to design, develop, and test the MFs and complementary technology (microfibre functionalisation, assembling, and electronic interconnection), in order to produce a biologically safe and effective bio-electronic system for the treatment of SCI. This goal will be achieved through five specific objectives: 1) To improve the electrical conductivity, strength, and chemical stability of the microfibres. 2) To develop electro-responsive engineered affibodies for microfibre functionalisation. 3) To develop the technology for MF interconnection and assembling into implantable systems. 4) To perform comprehensive investigation of the immunological, glial, neuronal, and connective tissue responses to the implanted MFs and applied electrostimulation in rodent and swine SCI models. 5) To investigate the motor and sensory effects of microfibre implantation and electrostimulation.

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