Nerve-Repair2.0
Financiado
Biodegradable MEMS implants for nerve repair
In this project, I will develop biodegradable MEMS (Micro-Electro-Mechanical Systems) implants for nerve repair, a new class of microsystems made entirely of biodegradable materials, including sensors, actuators, and electronics....
In this project, I will develop biodegradable MEMS (Micro-Electro-Mechanical Systems) implants for nerve repair, a new class of microsystems made entirely of biodegradable materials, including sensors, actuators, and electronics.
These wireless implants will focus on the mechanical stretching of peripheral nerves in vivo for neural regeneration after injury. Two strategies will be explored, compared, and combined: 1) cyclic mechanical nerve stimulation with NerveCyclicStretch, a soft biodegradable magnetic implant controlled by wireless magnetic actuation with an integrated strain sensor, and 2) constant mechanical traction with NerveSuctionStretch, a biodegradable implant applying negative pressure to the injured nerve with a biodegradable MEMS micropump and with an integrated pressure sensor. New biodegradable stretchable magnetic and conducting materials will be developed for this purpose, and in vivo studies on the sciatic nerve of rat models will be performed to demonstrate the proper operation of the implants and to identify the optimal mechanical stimulation parameters for nerve repair.
The development of new functional biodegradable materials (with tailored magnetic, electrical, and mechanical properties) and cleanroom-compatible fabrication processes (thin films deposition, photolithography, etching of biodegradable metals and polymer composites) will enable the realization of fully biodegradable microsystems while retaining the established advantages of MEMS (small size, high precision, fast response time, low energy consumption, reliable large-scale production).
This proposal is a paradigm shift in the design of medical devices, with biodegradable implants allowing for the first time the in vivo exploration of a promising new therapeutic approach. Beyond neurosciences, Nerve-Repair2.0 will pave the way for many other medical applications including cardiac diseases, addressing crucial societal challenges that could not be solved otherwise.
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Duración del proyecto: 61 meses
Fecha Inicio: 2023-09-22
Fecha Fin: 2028-10-31
Fecha Fin: 2028-10-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-09-22
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2023-STG:
ERC STARTING GRANTS
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
2M€
Líder del proyecto
TECHNISCHE UNIVERSITEIT DELFT
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5