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BEMOTHER

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Becoming a mother An integrative model of adaptations for motherhood during pre...

Becoming a mother An integrative model of adaptations for motherhood during pregnancy and the postpartum period. Pregnancy involves biological adaptations that are necessary for the onset, maintenance and regulation of maternal behavior. We were the first group to find (1, 2) that pregnancy is associated with consistent, pronounced and long-... see more

30/09/2025

UAB

2M€

Project Budget: 2M€

Project leader

UNIVERSITAT AUTÒNOMA DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 1268

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-09-09

ERC-2019-ADG: ERC Advanced Grant Scope:Objectives

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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4 Participantes

UAB

1.61M€ | Leader

DANOBAT S. COOP.

1.09M€ | participant

FUNDACION PARA LA INVESTIGAC...

522.53K€ | participant

Fundació Institut Hospital d...

334.07K€ | participant

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Project duration: 60 months Date Start: 2020-09-09
End date: 2025-09-30

Project leader

UNIVERSITAT AUTÒNOMA DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 1268

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description Pregnancy involves biological adaptations that are necessary for the onset, maintenance and regulation of maternal behavior. We were the first group to find (1, 2) that pregnancy is associated with consistent, pronounced and long-lasting reductions in cerebral gray matter (GM) volume in areas of the social-cognition network. The aim of BEMOTHER is to develop an integrative model of the adaptations for motherhood that occur during pregnancy and the postpartum period by: i) establishing when the brain of pregnant women begins to change and how it evolves; ii) characterizing the dynamics of cognitive performance, theory-of-mind, maternal-infant bonding and psychiatric measures; iii) assessing the effect of environmental and/or psychological factors in the maternal adaptations, iv) identifying the metabolomics biomarkers associated with maternal adaptations, and v) integrating the previous findings within the Research Domain Criteria framework (RDoC) (3). We will use a prospective longitudinal design at 5 time points (1 pre-pregnancy session, 2 intra-pregnancy sessions and 2 postpartum sessions) during which neuroimaging, psychological, behavioral and metabolomics data will be acquired in 3 groups of women: a group of nulliparous women who will be undergoing a full-term pregnancy, another group of nulliparous women whose same-sex partners will undergo a full-term pregnancy, and a group of control nulliparous women. We will provide the longitudinal RDoC-based model at the end of the study, but we will also deliver intermediate longitudinal evaluations after the postpartum session, as well as cross-sectional analyses after the first intra-pregnancy session and the postpartum session. BEMOTHER is timely and innovative. It adopts the translational RDoC framework in order to provide a pioneering, comprehensive and dynamic characterization of the adaptations for motherhood, addressing the interaction among different functional domains at different levels of analysis.

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