BASES CELULARES DE LA INTERACCION ENTRE OSCILADORES EN EL HIPOCAMPO NORMAL Y EPI...
BASES CELULARES DE LA INTERACCION ENTRE OSCILADORES EN EL HIPOCAMPO NORMAL Y EPILEPTICO
OSCILLATORY BRAIN ACTIVITY IN DIFFERENT FREQUENCY BANDS IS MODULATED BY COGNITIVE TASKS IN HUMANS AND ANIMALS, THESE OSCILLATIONS REFLECT ELECTROPHYSIOLOGICAL SIGNALS PRODUCED BY LARGE ENSEMBLES OF SYNCHRONIZED NEURONAL FIRING, IN...
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el día 2009-01-01
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Descripción del proyecto
OSCILLATORY BRAIN ACTIVITY IN DIFFERENT FREQUENCY BANDS IS MODULATED BY COGNITIVE TASKS IN HUMANS AND ANIMALS, THESE OSCILLATIONS REFLECT ELECTROPHYSIOLOGICAL SIGNALS PRODUCED BY LARGE ENSEMBLES OF SYNCHRONIZED NEURONAL FIRING, IN CONTRAST TO THE TRADITION OF CONSIDERING ISOLATED BRAIN RHYTHMS AS GENERATED IN SIMPLE CIRCUITS, RECENT DATA POINT TO COMPLEX WAVE PATTERNS CONSISTING ON SEVERAL OSCILLATORS GENERATED BY INTERACTING NETWORKS, THE MAIN GOAL OF THIS PROJECT IS TO UNDERSTAND HOW DIFFERENT HIPPOCAMPAL REGIONS DYNAMICALLY COORDINATE TO PRODUCE A RANGE OF OSCILLATORY PATTERNS IN THE NORMAL BRAIN, AND THE MECHANISMS UNDERLYING RHYTHM DISTORTION IN EPILEPSY, IN PARTICULAR, WE ARE INTERESTED IN THE CELLULAR BASIS OF RIPPLES AND FAST RIPPLES AND THEIR DYNAMICAL RELATIONSHIP IN PATHOLOGICAL CONDITIONS, WE WILL ALSO PURSUE DIFFERENT TYPES OF CROSS-FREQUENCY INTERACTIONS, INCLUDING PERIOD-DOUBLING, PERIOD CONCATENATION AND NESTED OSCILLATIONS IN THE THETA, GAMMA AND HIGHER FREQUENCY BANDS, TO THIS PURPOSE, WE WILL ADOPT A SINGLE-CELL AND MULTI-ELECTRODE APPROACH TOGETHER WITH SOPHISTICATED ANALYTICAL TOOLS TO TACKLE THESE QUESTION AT DIFFERENT LEVELS FROM SINGLE-CELL TO CIRCUIT DYNAMICS, WE WILL USE BOTH IN VITRO AND IN VIVO APPROACHES CURRENTLY AVAILABLE IN THE LAB AND WILL INTRODUCE CHRONIC RECORDING TECHNIQUES TO EVALUATE OSCILLATORY INTERACTIONS IN THE NON-ANESTHETIZED BRAIN, HIPOCAMPO\OSCILACIONES\ELECTROFISIOLOGIA\EPILEPSIA