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PHASTER

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Bacteriophages as vehicles for antimicrobial resistance determinants: Do they re...

Bacteriophages as vehicles for antimicrobial resistance determinants: Do they represent an environmental risk? Although antibiotic resistance is a major and growing public health concern, surveillance for the expansion of this phenomenon in environmental settings has not been fully explored. However, recent studies suggest that antibiotic... ver más

30/04/2025

FUNDACIO INSTITUT...

165K€

Presupuesto del proyecto: 165K€

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FUNDACIO INSTITUT CATALA DE RECERCA DEL AIGUA... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 50K€

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-02

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

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Duración del proyecto: 25 meses Fecha Inicio: 2023-03-02
Fecha Fin: 2025-04-30

Líder del proyecto

FUNDACIO INSTITUT CATALA DE RECERCA DEL AIGUA... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 165K€

Descripción del proyecto Although antibiotic resistance is a major and growing public health concern, surveillance for the expansion of this phenomenon in environmental settings has not been fully explored. However, recent studies suggest that antibiotic resistance found in clinical settings may emerge from environmental sources. In fact, the environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges, agricultural runoff, and animal feeding operations, which may contribute to the emergence and spread of antibiotic resistance. It is therefore necessary to understand the mechanisms and factors that promote antibiotic resistance. The PHASTER project aims at exploring the presence, diversity, and abundance of bacteriophages in the environment. Particular points of interest will be the study of bacteriophages that lead to the mobilization of antibiotic resistance genes (ARGs) and their interaction with antibiotic compounds, even at extremely low concentrations, similar to those found in some aquatic environments. Mesocosm experiments will also be conducted to examine how bacterial communities respond to the presence of bacteriophages harbouring ARGs under stressful conditions, such as exposure to antibiotics. In order to reach these goals, a combination of metagenomics and bioinformatics approaches will be used to investigate the sources of ARGs, their environmental distribution and how anthropogenic inputs affect their spread. A better understanding of the mechanisms and factors that contribute to antibiotic resistance will permit the implementation of appropriate public health strategies, policies, and mitigation programs. Special attention will also be devoted to dissemination so that stakeholders and policy makers can benefit from PHASTER.

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