BIOACTION
Financiado
Bacteria Biofilm as bio-factory for tissue regeneration
BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and fai...
BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone.BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project isstrongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine.As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine.
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Duración del proyecto: 47 meses
Fecha Inicio: 2023-04-01
Fecha Fin: 2027-03-31
Fecha Fin: 2027-03-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2022-PATHFINDEROPEN-01-01:
EIC Pathfinder Open 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
CONSIGLIO NAZIONALE DELLE RICERCHE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5