Innovating Works

AFM-LDH

Financiado
Atomic force microscopy-based exploration of layered double hydroxide nanopartic...
Atomic force microscopy-based exploration of layered double hydroxide nanoparticles adjuvant mechanism Layered double hydroxides nanoparticles (LDH NPs) composed by divalent/trivalent metal ions are efficient vaccine adjuvants to assist antigens to induce potent humoral and cellular immunity. However, the adjuvant mechanisms of LDH... Layered double hydroxides nanoparticles (LDH NPs) composed by divalent/trivalent metal ions are efficient vaccine adjuvants to assist antigens to induce potent humoral and cellular immunity. However, the adjuvant mechanisms of LDH NPs still remains elusive. Since the metal ion species and ratio are closely related to the adjuvant activity of LDH NPs, this study will investigate how the metal ion composition will affect the adjuvant activity of LDH NPs. Then, an atomic force microscopy (AFM)-based approach to physico-mechanically map the specific interaction occurring between NP and Toll-like receptor-4 or scavenger receptor A1 in vitro on living cells. Finally, the adjuvant signaling pathways of LDH NPs will be investigated in antigen presenting cells. This study will greatly advance the knowledge on the interplay among nanomaterials and innate immunity. The single-cell, quantitative approach can be readily applied to study the binding of other nanomaterials and the testing of anti-inflammatory molecules on living cells of the innate immune system. ver más
31/08/2025
AU
231K€
Duración del proyecto: 36 meses Fecha Inicio: 2022-08-01
Fecha Fin: 2025-08-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-01
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
Presupuesto El presupuesto total del proyecto asciende a 231K€
Líder del proyecto
AARHUS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5