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ASTROCYTES-REWARD

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Astrocytes in Reward and their Bidirectional Relationship with the Dopaminergic...

Astrocytes in Reward and their Bidirectional Relationship with the Dopaminergic System Astrocytes are currently investigated in a range of questions extending far beyond their traditional 'housekeeping' functions. We have contributed to expanding the horizon of functions attributable to astrocytes, and have recently... ver más

31/10/2028

THE HEBREW UNIVERS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-08

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

THE HEBREW UNIVERSITY OF JER...

2.34M€ | Lider

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Duración del proyecto: 67 meses Fecha Inicio: 2023-03-08
Fecha Fin: 2028-10-31

Líder del proyecto

THE HEBREW UNIVERSITY OF JERUSALEM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Astrocytes are currently investigated in a range of questions extending far beyond their traditional 'housekeeping' functions. We have contributed to expanding the horizon of functions attributable to astrocytes, and have recently identified a novel and unexpected role for hippocampal astrocytes in signaling the location of reward. This pioneering ERC project, will drive considerable progress in an important and completely unknown facet of reward-related information processing: the roles of hippocampal astrocytes in signaling reward, and their interaction with dopamine, the main player in the reward system. In Aim 1 we will define the role of hippocampal astrocytes in the perception of reward. We will test whether astrocytes can encode the presences of reward irrespective of its location, based on non-spatial (auditory) cues. By simultaneously imaging both astrocytes and neurons, we will delineate the spatio-temporal interplay between them in reward representation, and examine the projection-specific effect of astrocytes in rewarded behavior. Work on Aim 2 will delineate the effects of the dopaminergic system on astrocytes. We will comprehensively analyse the distribution of dopamine receptors on astrocytes and the astrocytic response to tonic vs. phasic dopaminergic signals. We will also perform simultaneous imaging of dopamine levels and astrocyte Ca2+ dynamics in different behavioral states. Aim 3 will determine how astrocytes mediate the effects of the dopaminergic system. We will do that by manipulating astrocytic activity measure pre-synaptic dopamine axonal release in the hippocampus and its influence on the poorly understood phenomenon of over-representation of reward locations by neuronal place cells. Our published work and our new (unpublished) results generate the conceptual basis for this proposal and demonstrate its technical feasibility. Achieving our goals will provide fundamental insights into the roles of astrocytes in information processing.

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