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ClimAHealth

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Assessing the role of climate adaptation on human evolution and its implications...

Assessing the role of climate adaptation on human evolution and its implications for health. Climate is a key environmental factor and one of the main selective pressures affecting the survival of organisms, including human beings. Human populations were exposed to a wide range of environmental conditions after the migrat... ver más

03/02/2025

UGR

264K€

Presupuesto del proyecto: 264K€

Líder del proyecto

UNIVERSIDAD DE GRANADA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 5512

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2025-02-03

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

UGR

263.73K€ | Lider

ARIZONA BOARD OF REGENTS

ABOR ARIZONA STATE UNIVERSIT...

177.27K€ | Participante

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Duración del proyecto: 44 meses Fecha Inicio: 2021-05-19
Fecha Fin: 2025-02-03

Líder del proyecto

UNIVERSIDAD DE GRANADA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 5512

Presupuesto del proyecto 264K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Climate is a key environmental factor and one of the main selective pressures affecting the survival of organisms, including human beings. Human populations were exposed to a wide range of environmental conditions after the migration Out of Africa, which could have shaped the evolution of traits related to metabolism, like thermoregulation. In this project, we will search for signals of selection caused by climate across the human genome to study climate adaptation in our species. We will assess the existence of recent and ancient events of selection using novel approaches that increase the statistical power respect to previous methods and control for many genomic confounding factors that are usually overlooked. We will combine bootstrapping and machine learning methods to this end. This project will focus on the influence of climate in the evolution of traits related to metabolism (thermoregulation in tissues like brown adipose tissue and skeletal muscle). We will also consider the influence of adaptive introgression from archaic humans (e.g. Neanderthals) that human populations encountered during their migrations. Finally, the evolutionary information generated will be used to inform genetic association studies and medical genetics. We will assess the influence of climate adaptation in current health issues by testing the relationship between climate-selected variants and prevalence of non-infectious chronic diseases. Finally, we will propose and test novel candidate genes for these diseases from genomic regions with high signals of climate selection.

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