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Assessing the risks of plant pathogen resistance evolution for the success of mi...

Assessing the risks of plant pathogen resistance evolution for the success of microbe-mediated biocontrol Microbe-mediated plant pathogen biocontrol has been suggested as an environmentally friendly alternative for agrochemicals to increase global food production. While biocontrol bacteria have been shown to suppress the growth of pla... see more

14/01/2026

HELSINGIN YLIOPIST...

216K€

Project Budget: 216K€

Project leader

HELSINGIN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-08-08

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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1 Participantes

HELSINGIN YLIOPISTO

215.53K€ | Leader

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Project duration: 29 months Date Start: 2023-08-08
End date: 2026-01-14

Project leader

HELSINGIN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 216K€

participation deadline Sin fecha límite de participación.

Project description Microbe-mediated plant pathogen biocontrol has been suggested as an environmentally friendly alternative for agrochemicals to increase global food production. While biocontrol bacteria have been shown to suppress the growth of plant pathogenic bacteria via the production of antimicrobials, it remains unclear whether pathogens can escape this by evolving resistance. The main aim of this proposal is to experimentally test whether plant pathogenic Ralstonia solanacearum bacterium can evolve resistant to Pseudomonas protegens biocontrol bacterium in the tomato plant rhizosphere. I will also test if pathogen resistance evolution results in co-evolution and increased antimicrobial activity of the biocontrol bacterium, and if microbial adaptations will affect how both bacteria interact with the tomato plant, potentially shifting plant-microbe interactions along the parasitism-mutualism continuum (virulence vs. plant growth-promotion). To achieve this, I will learn to use a novel experimental-evolution system that allows direct tracking of bacterial adaptation in the rhizosphere of tomatoes over successive plant generations. Training will also be provided to quantify bacterial adaptation using a combination of microbiological assays, genomics, metabolomics and plant assays. The proposed work will help to assess the potential risks of plant pathogen resistance evolution for the long-term efficiency of microbe-mediated biocontrol. It will also improve fundamental understanding of the rapid microbial evolution in an agriculturally relevant model system and help identify potentially novel antimicrobial compounds for future crop protection.

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