Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

Neurotoxic

Financiado

Cerrado

An Ultra sensitive Assay to Measure Oligomer Induced Toxicity in Human Cerebrosp...

An Ultra sensitive Assay to Measure Oligomer Induced Toxicity in Human Cerebrospinal Fluid The study of protein aggregates and how they damage neuronal cells is important in order to understand the initiation and progression of several neurodegenerative diseases - including Alzheimer’s disease (AD), Parkinson’s disease... ver más

31/07/2018

THE CHANCELLOR MAS...

195K€

Presupuesto del proyecto: 195K€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-07-31

MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual F...

I+D

Cerrada hace 9 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

THE CHANCELLOR MASTERS AND S...

195.45K€ | Lider

DOMENECH HERMANOS

595.02K€ | Participante

Proyectos interesantes

BFU2015-64119-P

Medical Technol...

Applied Physics

190K€ Cerrado

ADPROGRES

Medical Technol...

Applied Physics

75K€ Cerrado

METALZCOMP

Medical Technol...

Applied Physics

84K€ Cerrado

PID2019-109276RA-I00

Medical Technol...

Applied Physics

157K€ Cerrado

BES-2016-076253

Medical Technol...

Applied Physics

93K€ Cerrado

SAF2010-18837

Medical Technol...

Applied Physics

133K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 29 meses Fecha Inicio: 2016-02-24
Fecha Fin: 2018-07-31

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 195K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The study of protein aggregates and how they damage neuronal cells is important in order to understand the initiation and progression of several neurodegenerative diseases - including Alzheimer’s disease (AD), Parkinson’s disease (PD). The aggregation from the native monomeric proteins to beta sheet containing amyloid structures involves the formation of different species - misfolded proteins, small soluble oligomers and finally formation of fibrils. It is believed that small oligomers are the most cytotoxic species which play a major role in neuronal loss and cell death. Although, the exact mechanism and extent of amyloid oligomer’s cytotoxicity is still unknown, one of the most consistent pathologies in neurodegenerative disease is unregulated influx of Ca2+ into the cell. Individual oligomers directly disrupt cell membranes through non-specific binding at picomolar concentrations leading to the formation of ion channels, which allow Ca2+ influx and can lead to cell death. Based on this observation, we will develop a single liposome assay to quantify the oligomer induced toxicity from oligomers present in human cerebrospinal fluid (CSF) from healthy controls and patients with AD and PD. Using a Ca2+ sensitive fluorogenic sensor, we will monitor the oligomer induced Ca2+ influx inside the liposome in real time. We will measure and compare the toxicity of synthetic oligomers of amyloid beta, alpha-synuclein, tau and PrP oligomers as a function of oligomer concentration and liposome membrane composition. We will then quantify the effect of various antibodies commonly used for treatment of AD and PD on the toxicity of synthetic oligomers and those in CSF. This novel ultra-sensitive state-of-the-art single molecule technique will provide new insights into the mechanism of oligomer induced toxicity, allowing us to identify the most toxic oligomers and the most suitable antibodies to prevent oligomer induced damage as well as having potential for early disease diagnosis.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores