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EU-ToxRisk

Financiado

Cerrado

An Integrated European Flagship Program Driving Mechanism based Toxicity Testi...

An Integrated European Flagship Program Driving Mechanism based Toxicity Testing and Risk Assessment for the 21st Century The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to est... ver más

31/12/2021

ULEI

30M€

Presupuesto del proyecto: 30M€

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 45 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-12-31

PHC-33-2015: New approaches to improve predictiv...

I+D

Cerrada hace 9 años

0% 92% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

45 Participantes

ULEI

5.03M€ | Lider

KU Leuven

790.69K€ | Participante

UNILEVER U.K. CENTRAL RESOUR...

21.00K€ | Participante

INSPHERO

861.51K€ | Participante

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Duración del proyecto: 75 meses Fecha Inicio: 2015-09-11
Fecha Fin: 2021-12-31

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 30M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.

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