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NVU-Chip

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An in vitro 3D microfluidic human NeuroVascular Unit model for identifying the c...

An in vitro 3D microfluidic human NeuroVascular Unit model for identifying the cell type specific responses to diverse inflammatory stimuli in the brain capillaries Neurological disorders affect many people's life, contributing to significant mortality and morbidity in the modern world, with 16.5% of global deaths and are the leading cause of disability, affecting 276 million people's daily l... ver más

31/05/2023

SABANCI UNIVERSITY

157K€

Presupuesto del proyecto: 157K€

Líder del proyecto

SABANCI UNIVERSITESI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-05-31

WF-03-2020: Widening Fellowships Specific Challenge:The Marie Skłodowska-Curie actions (MSCA) contribute to boosting jobs, growth and...

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1 Participantes

SABANCI UNIVERSITY

157.36K€ | Lider

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Duración del proyecto: 25 meses Fecha Inicio: 2021-04-15
Fecha Fin: 2023-05-31

Líder del proyecto

SABANCI UNIVERSITESI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 157K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Neurological disorders affect many people's life, contributing to significant mortality and morbidity in the modern world, with 16.5% of global deaths and are the leading cause of disability, affecting 276 million people's daily lives. Many of these diseases, including Alzheimer’s and Multiple Sclerosis, are related with the impaired blood-brain barrier (BBB) function. Unfortunately, neither animal models of the neurovascular unit (NVU) nor in vitro cultures of primary or immortalized human brain microvascular endothelial cells (BMVECs) alone effectively mimic the barrier, and transporter functions of the BBB observed in humans. Thus, there is a great need for human NVU models to recapitulate in vivo human physiology in health and disease conditions and understand the cellular mechanisms and changes in disease conditions. This project aims to develop a 3D NVU model to identify the cell-type-specific responses to diverse inflammatory stimuli in the NVU. The NVU-Chip project will the first model providing such a complex cellular environment in a unique microfluidic device to fully recapitulating human NVU in vitro utilizing relevant mechanobiological forces. Additionally, The NVU-Chip will improve the state-of-the-art by incorporating cyclic mechanical strain in a BBB model for the first time. This project will combine and amend the state-of-the-art stem cell technologies to differentiate all brain cells, and advanced microfabrication approaches to design and fabricate the microfluidic chips using the most appropriate materials ECM coatings for co-culturing all cell types in the same device. The human-based NVU-Chip model will also give a new approach for studying cellular responses to diverse inflammatory stimuli, identifying key inflammatory factors of CNS related diseases. Outcomes of the NVU-Chip project will enhance the existing knowledge and technologies, yielding high-impact journal publications, as well as potential commercial product in the long term.

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