Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ChondroGEL

Financiado

Cerrado

Advanced Protein Based Materials for Cartilage Repair

Osteoarthritis (OA) is a type of joint disease that results from breakdown of cartilage and subsequent damage to the underlying bone. Polymeric biomaterials have rapidly expanded to promote cell differentiation and tissue regenera... ver más

31/03/2024

UoB

213K€

Presupuesto del proyecto: 213K€

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-03-31

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UoB

212.93K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MAT2015-73656-JIN DESARROLLO DE HIDROGELES BIOMIMETICOS Y ANDAMIOS TISULARES P... 205K€ Cerrado

HYDROZONES Bioactivated hierarchical hydrogels as zonal implants for ar... 13M€ Cerrado

PEPTIDOPAMIN Molecular design of biologically inspired soft materials for... 185K€ Cerrado

GAMBA Gene Activated Matrices for Bone and Cartilage Regeneration... 4M€ Cerrado

PCIN-2015-261 NANOCOMPOSITES JERARQUICOS DOPADOS IONICAMENTE COMO SOPORTES... 110K€ Cerrado

CTQ2017-88158-R DISEÑO DE GELES HIBRIDOS DE GRAFENO PARA EL CULTIVO DE CELUL... 134K€ Cerrado

Duración del proyecto: 36 meses Fecha Inicio: 2021-03-18
Fecha Fin: 2024-03-31

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 213K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Osteoarthritis (OA) is a type of joint disease that results from breakdown of cartilage and subsequent damage to the underlying bone. Polymeric biomaterials have rapidly expanded to promote cell differentiation and tissue regeneration, and are uniquely placed to provide sophisticated solutions for the treatment of OA. Among them, hydrophilic, biocompatible 3D networks, called hydrogels, represent the gold standard for tissue regeneration, owing to their high-water content and tuneable mechanical properties. However, incorporation in hydrogels of proteins and growth factors that are essential to induce tissue differentiation, is not trivial. By merging advanced hydrogel technology and cutting-edge cell biology research, we propose to develop a novel in situ protein-based crosslinked hydrogel system based on chondrogenic bioconjugates for controlled cellular differentiation. This unique approach allows for non-surgical administration of hydrogels with controlled and tuneable mechanical properties that retain their protein cargo at the treatment site. Furthermore, as the hydrogel is directly built from the required growth factors, even distribution throughout the macromaterial is ensured. This new treatment modality will allow for both short-term relief of pain through mechanical support of the inflamed joint, while providing important biological cues for the differentiation of administered stem cells into chondrocytes for cartillage repair. Furthermore, the implementation of a fluorescence life-time imaging microscopy (FLIM) approach for monitoring changes in cell behaviour will allow for rapid identification of lead materials significantly earlier in the development pipeline than is currently available through conventional methods. While this work is focused on developing hydrogels for cartilage repair, it is envisaged that the knowledge and experience gained throughout this project will allow for other therapeutic targets to be explored in the future.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores