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ADMAIORA

financed

ADvanced nanocomposite MAterIals fOr in situ treatment and ultRAsound mediated m...

ADvanced nanocomposite MAterIals fOr in situ treatment and ultRAsound mediated management of osteoarthritis Osteoarthritis (OA) is a major burden that affects ~ 40 million of EU citizens, with enormous direct and indirect costs for the European healthcare systems, quantified in ~ 50.4 billion euros per year. This disease involves the de... see more

31/12/2023

SSSA

5M€

Project Budget: 5M€

Project leader

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI P... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2023-12-31

NMBP-22-2018: Osteoarticular tissues regeneration... Specific Challenge:EU demographic change requires innovation to enhance active ageing, whereby a gro...

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Cerrada does 7 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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8 Participantes

SSSA

1.37M€ | Leader

IGT

586.00K€ | participant

VIMEX

495.13K€ | participant

IOR

1.29M€ | participant

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Project duration: 60 months Date Start: 2018-12-12
End date: 2023-12-31

Project leader

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI P... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 5M€

participation deadline Sin fecha límite de participación.

Project description Osteoarthritis (OA) is a major burden that affects ~ 40 million of EU citizens, with enormous direct and indirect costs for the European healthcare systems, quantified in ~ 50.4 billion euros per year. This disease involves the degeneration of cartilage and other joint structures and is one of the most common causes of pain and disability in middle-aged and elderly people. ADMAIORA aims in the long-term at increasing the healthy and active lifespan of people affected by OA, by considerably slowing down or even stopping the degeneration process, thus delaying or avoiding surgical interventions for total joint replacement. Within the project time-frame the target is to achieve a 60% reduction of degeneration in OA animal models treated with the ADMAIORA technologies, with respect to control (untreated) ones, after 4 weeks, and a 90% reduction after 3 months. To achieve this ambitious objective the Consortium will evolve and merge technologies that already showed a high potential as experimental proof of concepts (TRL = 3) and will bring them at a preclinical level (TRL = 5). The ADMAIORA Consortium will develop biosynthetic hydrogels embedded with carbon-based nanomaterials, conferring higher mechanical and lubrication properties, and piezoelectric nanoparticles enabling responsivity to remote wireless ultrasound waves. Stem cells derived from autologous adipose tissue, which already demonstrated anti-inflammatory and regenerative properties, will be entrapped in the hydrogels. Materials and cells will be delivered in situ through an innovative handheld 3D bioprinter, embedded in an arthroscopic tool. A custom brace will be designed and equipped with ultrasound probes for both monitoring the joint status and stimulating the implanted piezoelectric nanobiomaterial. A dedicated App will allow a direct connection between patient and physician in an Internet of Things framework. Overall, ADMAIORA will target a ground-breaking paradigm that may revolutionize OA treatment.

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