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ADVANC1-METH

Financiado

Cerrado

ADVANced engineering of C1 metabolism towards METHanol based sustainable biotech...

ADVANced engineering of C1 metabolism towards METHanol based sustainable biotechnology Urgent global problems, including climate change and fossil-fuel dependence, force the EU to develop sustainable bio-basedchemical production platforms. However, current biotechnological feedstocks, such as plant-based sugars, suf... ver más

31/10/2023

188K€

Presupuesto del proyecto: 188K€

Líder del proyecto

WAGENINGEN UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-10-31

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

187.57K€ | Lider

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Duración del proyecto: 31 meses Fecha Inicio: 2021-03-31
Fecha Fin: 2023-10-31

Líder del proyecto

WAGENINGEN UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 188K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Urgent global problems, including climate change and fossil-fuel dependence, force the EU to develop sustainable bio-basedchemical production platforms. However, current biotechnological feedstocks, such as plant-based sugars, suffer from serious limitations in terms of availability and sustainability. A very promising alternativeis the one-carbon (C1) feedstock methanol, which canbe produced in a sustainable manner from waste, or CO2 and renewable hydrogen. So far, the conversion of methanol to products is limited by the lack of suitable, efficientmicrobial cell factories. Hence, this project will engineer a highly efficient, synthetic methanol assimilation pathway into the well-known industrial host bacterium Escherichia coli. First, modular optimization will be performed for the bottleneck steps of enzymatic methanol conversion in the cell. Then, the overall strain performance will be optimized by rational, systems-wide targeting of the metabolic network and fast growing strains on methanol will be selected and studied. To achieve the objectives an innovative high-throughput genome editing approach will be employed. ADVANC1-METH is expected to yield a bacterial platform strain for efficient conversion of methanol to products, and industrially relevant IP and scientific knowledge will be effectively disseminated. The ADVANC1-METH project will aid the applicant to further extend his knowledge in the interdisciplinary fields of synthetic biology, bioinformatics, genetic and metabolic engineering, and complement his academic skills to fulfil the ambition to become an independent researcher. The implementation and training will be hosted at an institute with key expertise in bacterial and metabolic engineering. Within the ADVANC1-METH project videos and a board game will be developed to increase public engagement and knowledge on sustainable and methanol-based biotechnology, which are essential to realize a sustainable bio-based society.

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