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ScoliStorm

Financiado

Adolescent Idiopathic Scoliosis a Perfect Storm of Functional Anatomy Biomecha...

Adolescent Idiopathic Scoliosis a Perfect Storm of Functional Anatomy Biomechanics and Mechanobiology during Growth? Adolescent idiopathic scoliosis (AIS) is a 3D deformity of the spine affecting previously healthy children, substantially reducing their quality of life and creating a life-long burden of disease. Although it has been indentified... ver más

30/09/2026

TU/e

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

TECHNISCHE UNIVERSITEIT EINDHOVEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-07-28

ERC-2020-ADG: ERC ADVANCED GRANT

I+D

Cerrada hace 4 años

0% 100% 100%

3 Participantes

TU/e

1.82M€ | Lider

BERMAQ

376.08K€ | Participante

UMC UTRECHT

919.06K€ | Participante

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Duración del proyecto: 62 meses Fecha Inicio: 2021-07-28
Fecha Fin: 2026-09-30

Líder del proyecto

TECHNISCHE UNIVERSITEIT EINDHOVEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Adolescent idiopathic scoliosis (AIS) is a 3D deformity of the spine affecting previously healthy children, substantially reducing their quality of life and creating a life-long burden of disease. Although it has been indentified since the time of Hippocrates (400 BC), we have not been able to rationally develop effective treatments and provide a cure for these children suffering from AIS because its cause and mechanism of disease are still unknown. ScoliStorm will create a paradigm shift in AIS research by uncovering its complex perfect storm of anatomical, biomechanical and mechanobiological causes in the intervertebral disc and exploring this disease mechanism whereby predictive triggers are identified that can be used for prevention and early treatment. We will study human subjects non-invasively through disease initiation and progression, creating for the first time a comprehensive dataset of healthy and scoliotic human spines that can be used for early detection and treatment of juvenile spine conditions. We will create safe non-radiographic accurate imaging of the osseous spine, available in most hospitals, which can become the standard for diagnosis and monitoring of osseous injury and disease in juveniles. We will develop high-throughput creation and use of subject specific in silico models, allowing simulation of organ and tissue function such that morphological imaging data can provide functional analysis of the patient for diagnosis and treatment. Mechanisms affecting tissue adaptation will be mapped and show that normal processes by their coincidence can create an aberrant response and disease, providing an explanation applicable for other multifactorial diseases. Thus, a unique dedicated and complete multidisciplinary process, combining 1) bioengineering analysis, exploiting imaging, in silico modeling, in vitro and ex vivo approaches in humans, and 2) clinical medicine, also applicable for exploring other multifactorial diseases, will be created.

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