Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

ActSwiftly

Financiado

Activation and switch of fates in T lymphocytes.

Antigen-stimulated naïve CD8+ T cells proliferate and differentiate into effector and memory cells. Whereas effector T cells remove infected or cancerous cells, memory T cells protect the organism from re-infections. Despite decad... ver más

31/12/2029

IMG

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE... No se ha especificado una descripción o un objeto social para esta compañía.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-14

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2023-COG: ERC CONSOLIDATOR GRANTS

I+D

Cerrada hace 1 año

0% 100% 100%

1 Participantes

IMG

2.63M€ | Lider

Proyectos interesantes

TILC Targeting Innate Lymphoid Cells 3M€ Cerrado

SCIMAP Roads to memory Studying the regulation of lymphocyte stemn... 1M€ Cerrado

SAF2011-22463 MECANISMOS MODULADORES DE LA DIFERENCIACION Y ACTIVIDAD FUNC... 200K€ Cerrado

RTI2018-095673-B-I00 INTEGRACION DE SEÑALES DEL TCR Y EL COMPLEMENTO POR LOS LINF... 327K€ Cerrado

SAF2012-39536 FUNCION DE LA MOLECULA CD229 (LY9), UN MIEMBRO DE LA FAMILA... 145K€ Cerrado

SAF2010-19717 IMPLICACIONES FUNCIONALES Y TERAPEUTICAS DEL RECONOCIMIENTO... 339K€ Cerrado

Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 69 meses Fecha Inicio: 2024-03-14
Fecha Fin: 2029-12-31

Presupuesto del proyecto 3M€

Descripción del proyecto Antigen-stimulated naïve CD8+ T cells proliferate and differentiate into effector and memory cells. Whereas effector T cells remove infected or cancerous cells, memory T cells protect the organism from re-infections. Despite decades of research, the challenging central questions of how naïve T cells form diverse progeny and what drives the differential response of naïve and memory T cells to infection remain unanswered, largely because of lacking experimental tools. The goal of this project is to generate a comprehensive model of cell-fate choices of naïve and memory CD8+ T cells in vivo. We will achieve this by addressing three complementary specific objectives: 1) To understand the early and late fate choices in naïve T cells. 2) To uncover differences between naïve and memory T-cell responses and fates. 3) To identify the role of proximal protein kinases LCK and FYN in T-cell fate choices. We will pursue these aims using a combination of experimental immunology and systems biology. We used the synergy between novel genetic models and single cell atlases (i) to characterize an unprecedented transient stage of activated T cells, (ii) to determine the early gene expression signatures and fate choices of in vivo activated naïve and memory T cells, and (iii) to observe that LCK secures memory T-cell formation. These tools and findings offer us novel perspectives to tackle the challenging objective in its full complexity. We will develop additional unique experimental models coupled with innovative in-silico techniques to uncover the cellular and molecular mechanisms underlying diverse fate choices of particular T-cell subsets and to narrow the gap between mouse and human immunology. Overall, this project has the ambition to resolve long-standing fundamental questions in immunology to open new avenues for targeting and modulating T-cell fates in vivo for efficient vaccine design and for promoting beneficial cytotoxic responses to chronic infections and cancer.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores