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ACINETWORK

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A training network for the design of synthetic carbohydrate based vaccines in th...

A training network for the design of synthetic carbohydrate based vaccines in the fight against multi drug resistant nosocomial pathogen Acinetobacter baumannii Bacterial infections are a societal burden with profound medical and socio-economic impacts. Although antibiotics can be effective, the continuous emergence of bacteria with antimicrobial resistance calls for the introduction of n... ver más

31/01/2028

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3M€

Presupuesto del proyecto: 3M€

Líder del proyecto Líder desconocido

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-11-14

HORIZON-MSCA-2022-DN-01-01: MSCA Doctoral Networks 2022 Expected Outcome:Project results are expected to contribute to the following outcomes:

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16 Participantes

CONSIGLIO NAZIONALE DELLE RI...

ATTANA AB

MAX-PLANCK-GESELLSCHAFT ZUR...

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Duración del proyecto: 50 meses Fecha Inicio: 2023-11-14
Fecha Fin: 2028-01-31

Líder del proyecto Líder desconocido

Presupuesto del proyecto 3M€

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Descripción del proyecto Bacterial infections are a societal burden with profound medical and socio-economic impacts. Although antibiotics can be effective, the continuous emergence of bacteria with antimicrobial resistance calls for the introduction of novel therapeutics. In this regard, glycoconjugate vaccines (GV) hold a prominent role in the fight against AMR bacterial strains. They are based on the chemical conjugation of one or more pathogen-associated saccharide antigens to immunogenic carriers, leading to a long-term protective immunity. ACINETWORK will focus on the development of GV against severe and life-threatening infections caused by antimicrobial resistant Acinetobacter baumannii strains, which are a major cause of nosocomial diseases and for which no vaccine exists. ACINETWORK wants to overcome the limitations of currently licensed GV, due to highly heterogeneous composition and batch wise variability, by innovatively using structurally-defined synthetic oligosaccharide antigens to develop GV with well-defined composition, higher purity and better safety profiles. The manufacturing of such GV is also more rapid and cost-effective. Thus, this project will set synthesis and testing pipelines that will serve as the prototype for the development of GV against other bacteria. The ACINETWORK consortium comprises universities and SMEs with a unique complementary expertise, ranging from carbohydrate chemistry to nanotechnology, immunology and microbiology, which garantees the realization of the new GV. The goal of ACINETWORK is to also forge 10 young experts in the design of these novel medical solutions with an integrated training program, which will equip them with a large battery of scientific and transferable skills. The multidisciplinarity of the consortium ensures a fertile and stimulating environment in which these young researchers will acquire unique competencies in vaccine design, development and production, which will be central at putting Europe at the forefront of GV.

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