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RESOLVE

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A systems biology approach to RESOLVE the molecular pathology of two hallmarks o...

A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co morbidities hypertriglyceridemia and low HDL cholesterol Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density... see more

30/06/2018

UNIVERSITAIR MEDIS...

14M€

Project Budget: 14M€

Project leader

ACADEMISCH ZIEKENHUIS GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 12 Participantes

Financing granted El organismo FP7 notifico la concesión del proyecto The day 2018-06-30 We do not have the information of the call

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

12 Participantes

UNIVERSITAIR MEDISCH CENTRUM...

0.00€ | Leader

Academisch Medisch Centrum A...

N.D. | participant

UGOT - GOETEBORGS UNIVERSITE...

N.D. | participant

GENEXPLAIN

N.D. | participant

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Project leader

ACADEMISCH ZIEKENHUIS GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 14M€

participation deadline Sin fecha límite de participación.

Project description Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CVD; type 2 diabetes, T2DM; non-alcoholic fatty liver disease, NAFLD). RESOLVE will deliver on 6 specific objectives: i) build a computational model for analyzing the kinetics of plasma lipids, lipoproteins and their interactions with glucose metabolism. ii) apply the iterative systems biology cycle for calibrating, validating and improving the computational model in dedicated studies in mice iii) build, calibrate and validate the computational model for use in humans. iv) analyze – based on model and experimental data – which processes in the murine metabolic network regulate the physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact. v) analyze – based on model and experimental data – which processes in the human metabolic network regulate the physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact vi) use the human model to identify network-based drug targets aimed at restoring the metabolic dyslipidemia and glycemic control in patients with MetS and associated comorbidities. RESOLVE 60-months project will result into a novel strategy for development of therapeutic strategies for MetS patients with T2DM, NAFLD or CVD.

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