SynMech
Financiado
A synaptic mechanogenetic technology to repair brain connectivity
We aim to develop a mechanogenetic technology to regulate functional connectivity of neural circuits, and show how it can be harnessed for therapeutic purposes in high-prevalence treatment-resistant brain disorders.Mechanogenetics...
We aim to develop a mechanogenetic technology to regulate functional connectivity of neural circuits, and show how it can be harnessed for therapeutic purposes in high-prevalence treatment-resistant brain disorders.Mechanogenetics is an emerging field of health science that attempts to regulate neural networks by combining the advantages of optogenetics with those of magneto-mechanical stimulations; like optogenetics, it relies on targeted actuators to achieve circuit specificity, while exploiting magnetic fields to remotely stimulate the brain. Yet, despite solid theoretical foundations and encouraging experimental results, we are to date unable to repair a dysfunctional brain using mechanogenetics due to technological barriers in spatial resolution and in vivo implementation.We propose an innovative solution based on functionalized biocompatible magnetic nanoparticles and bioengineered synaptic mechanosensors that synergistically integrate at specific synaptic connections to bidirectionally regulate brain circuit connectivity in response to focused magnetic fields of different frequencies delivered via high-permeability transcranial magnetic stimulators. By hijacking the signaling pathways of synaptic mechanosensors, we aim to promote a normalization of neural circuit activity that outlasts the therapeutic intervention. We will assess the capacity of the synaptic mechanogenetic toolkit to promote and depress network activity in mouse models of stroke and epilepsy.To achieve this ambitious goal, we have gathered an interdisciplinary consortium going from material scientists and electronic experts to physiologists and clinicians. Our approach, based on magnetic fields that penetrate brain tissue unimpeded, is predicted to go beyond current therapeutic paradigms because it does not require implantation of invasive devices, and at the same time, promises to achieve subcellular resolution for repairing connectivity defects that underlie most brain disorders.
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Duración del proyecto: 59 meses
Fecha Inicio: 2023-02-01
Fecha Fin: 2028-01-31
Fecha Fin: 2028-01-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-02-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2022-PATHFINDEROPEN-01-01:
EIC Pathfinder Open 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
UNIVERSITA DEGLI STUDI DI TRIESTE
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5