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PRIME

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A Personalised Living Cell Synthetic Computing Circuit for Sensing and Treating...

A Personalised Living Cell Synthetic Computing Circuit for Sensing and Treating Neurodegenerative Disorders There remain urgent and unmet needs for the treatment of neurological diseases. Epilepsy is a serious, chronic brain disease characterized by recurrent seizures. Closed-loop, implanted devices offer ways to reduce seizures in drug... see more

31/01/2025

SOUTH EAST TECHNOL...

4M€

Project Budget: 4M€

Project leader

SOUTH EAST TECHNOLOGICAL UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 8 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2025-01-31

FETOPEN-01-2018-2019-2020: FET-Open Challenging Current Thinki... Specific Challenge:to lay the foundations for radically new future technologies of any kind from vis...

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Cerrada does 7 years

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

8 Participantes

SOUTH EAST TECHNOLOGICAL UNI...

706.88K€ | Leader

SERVICIOS PROFESIONALES DE A...

124.14K€ | participant

EPOS IASIS

528.80K€ | participant

Unife

681.61K€ | participant

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Project duration: 48 months Date Start: 2021-01-19
End date: 2025-01-31

Project leader

SOUTH EAST TECHNOLOGICAL UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

Project Budget 4M€

participation deadline Sin fecha límite de participación.

Project description There remain urgent and unmet needs for the treatment of neurological diseases. Epilepsy is a serious, chronic brain disease characterized by recurrent seizures. Closed-loop, implanted devices offer ways to reduce seizures in drug-resistant patients but their efficacy is poor and they interrupt seizures only after they begin. PRIME capitalizes on a breakthrough discovery that transfer RNA (tRNA) fragments, a novel class of noncoding RNA, increase in patients in advance of when a seizure occurs. We propose to engineer human cells to respond to tRNA fragment elevations as the trigger for pre-emptive release of glial-derived neurotrophic factor (GDNF), a seizure-suppressing and disease-modifying treatment. Artificial Intelligence (AI) algorithms will be used to integrate OR or AND logic gate functions in the switching process, depending on the quantity and type of tRNA fragments and timing of their release in a given epileptic network and a second, fail-safe calcium-dependent pathway will allow GDNF release in the event of a breakthrough seizure. This enables a precise level of personalization in the design of the bio-computing cells, which will be encapsulated into a membrane device within the microenvironment scaffold, enabling the engineered cells to co-exist with natural brain tissue. Validation of the bio-computing cells will be tested in both in vitro microfluidic organ-on-a-chip as well as in vivo tests for effects on spontaneous seizures in rodents with epilepsy. PRIME’s results will provide a transformational diagnostic-therapeutic treatment for epilepsy and other neurological diseases that feature disrupted neuronal network function.

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